Equivalent T cell epitope promiscuity in ecologically diverse human pathogens

The HLA (human leukocyte antigen) molecules that present pathogen-derived epitopes to T cells are highly diverse. Correspondingly, many pathogens such as HIV evolve epitope variants in order to evade immune recognition. In contrast, another persistent human pathogen, Mycobacterium tuberculosis, has...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e73124
Hauptverfasser:	Wiens, Kirsten E, Swaminathan, Harish, Copin, Richard, Lun, Desmond S, Ernst, Joel D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS AIDS vaccines Algorithms Alleles Analysis Antigenic determinants Antigens Antigens, Bacterial - genetics Antigens, Bacterial - immunology Bacillus anthracis - genetics Bacillus anthracis - immunology Bacteria Bacterial Toxins - genetics Bacterial Toxins - immunology Binding Bioinformatics Clostridium tetani - genetics Clostridium tetani - immunology Computer science Conservation Epitopes Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - immunology Equivalence Gene Frequency Genetic Variation - immunology Health aspects Histocompatibility antigen HLA HIV HIV - genetics HIV - immunology HLA antigens HLA-A Antigens - genetics HLA-A Antigens - immunology HLA-B Antigens - genetics HLA-B Antigens - immunology HLA-DR Antigens - genetics HLA-DR Antigens - immunology Human immunodeficiency virus Humans Immune Evasion - genetics Immunogenicity Immunology Leukocytes Lymphocytes Lymphocytes T Medicine Microorganisms Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - immunology Neural networks Pathogenic microorganisms Pathogens Pathology Peptides Promiscuity Streptococcus infections Streptococcus pyogenes - genetics Streptococcus pyogenes - immunology T cells T-Lymphocytes - immunology T-Lymphocytes - microbiology T-Lymphocytes - virology Tetanus Toxin - genetics Tetanus Toxin - immunology Toxins Tuberculosis Vaccines
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