Inhibitory peptide of mitochondrial μ-calpain protects against photoreceptor degeneration in rhodopsin transgenic S334ter and P23H rats

Mitochondrial μ-calpain and apoptosis-inducing factor (AIF)-dependent photoreceptor cell death has been seen in several rat and mouse models of retinitis pigmentosa (RP). Previously, we demonstrated that the specific peptide inhibitor of mitochondrial μ-calpain, Tat-µCL, protected against retinal de...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e71650-e71650
Hauptverfasser:	Ozaki, Taku, Ishiguro, Sei-ichi, Hirano, Satoshi, Baba, Ayaka, Yamashita, Tetsuro, Tomita, Hiroshi, Nakazawa, Mitsuru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Apoptosis Apoptosis Inducing Factor - antagonists & inhibitors Apoptosis Inducing Factor - genetics Apoptosis Inducing Factor - metabolism Apoptosis-inducing factor Biology Calpain Calpain - antagonists & inhibitors Calpain - genetics Calpain - metabolism Cell death Cell Death - drug effects Cell Nucleus - drug effects Cell Nucleus - metabolism Chemistry Degeneration Disease Models, Animal DNA nucleotidylexotransferase Electroretinograms Electroretinography Gene Expression Regulation Immunohistochemistry In Situ Nick-End Labeling Inhibition Injection Intravitreal Injections Medical personnel Medicine MERTK gene Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondrial Proteins - antagonists & inhibitors Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Mortality Mutation Nuclear transport Ophthalmic Solutions Peptides - chemical synthesis Peptides - pharmacology Photoreceptor Cells, Vertebrate - drug effects Photoreceptor Cells, Vertebrate - metabolism Photoreceptor Cells, Vertebrate - pathology Protein Transport - drug effects Rats Rats, Transgenic Retina Retinal degeneration Retinitis Retinitis pigmentosa Retinitis Pigmentosa - drug therapy Retinitis Pigmentosa - genetics Retinitis Pigmentosa - metabolism Retinitis Pigmentosa - pathology Rhodopsin Rhodopsin - genetics Rhodopsin - metabolism Rodents Signal Transduction Topical application Transgenic Translocation
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