532 nm low-power laser irradiation recovers γ-secretase inhibitor-mediated cell growth suppression and promotes cell proliferation via Akt signaling

The γ-secretase inhibitor (GSI) has been shown to inhibit expression of amyloid beta (Aβ), but GSI also has a side effect of reducing cell survival. Since low-power laser irradiation (LLI) has been known to promote cell survival, we examined whether 532 nm LLI can rescue the GSI side effect or not....

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e70737
Hauptverfasser:	Fukuzaki, Yumi, Sugawara, Haruna, Yamanoha, Banri, Kogure, Shinichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism AKT protein Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - metabolism Apoptosis Biology Cell activation Cell culture Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cell Proliferation - radiation effects Cell survival Cell Survival - drug effects Cell Survival - radiation effects Dose-Response Relationship, Radiation Fluorescence Fluorescent Antibody Technique Glioblastoma Glioblastoma cells Humans Inhibitors Irradiated Irradiation Kinases Lasers Low-Level Light Therapy Medicine Oligopeptides - pharmacology Phosphorylation - drug effects Phosphorylation - radiation effects Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - metabolism PTEN protein Secretase Side effects Signal Transduction - drug effects Signal Transduction - radiation effects Signaling Survival
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