Electronegative low-density lipoprotein increases C-reactive protein expression in vascular endothelial cells through the LOX-1 receptor

Increased plasma C-reactive protein (CRP) levels are associated with the occurrence and severity of acute coronary syndrome. We investigated whether CRP can be generated in vascular endothelial cells (ECs) after exposure to the most electronegative subfraction of low-density lipoprotein (LDL), L5, w...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e70533-e70533
Hauptverfasser:	Chu, Chih-Sheng, Wang, Yu-Chen, Lu, Long-Sheng, Walton, Brian, Yilmaz, H Ramazan, Huang, Roger Y, Sawamura, Tatsuya, Dixon, Richard A F, Lai, Wen-Ter, Chen, Chu-Huang, Lu, Jonathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute coronary syndromes Adult Anticholesteremic Agents - therapeutic use Antilipemic agents Aorta Atherogenesis Atherosclerosis Atorvastatin Binding sites Biology C-reactive protein C-Reactive Protein - analysis C-Reactive Protein - metabolism Cardiology Cardiovascular disease Cell adhesion & migration Cells, Cultured Chemistry Cholesterol Coronary heart disease Cysteine Electronegativity Endothelial cells Endothelial Cells - metabolism Endothelium Female Fibroblasts Growth factors Heart Heptanoic Acids - therapeutic use Hospitals Humans Hypercholesterolemia Hypercholesterolemia - blood Hypercholesterolemia - drug therapy Hypercholesterolemia - metabolism Internal medicine Lectins Lipids Lipoproteins, LDL - blood Lipoproteins, LDL - metabolism Liquid oxygen Low density lipoprotein Low density lipoproteins LOX-1 protein Male Medical research Medicine Microscopy Middle Aged Oxygen Patients Proteins Pyrroles - therapeutic use Reactive oxygen species Reactive Oxygen Species - metabolism Rodents Scavenger Receptors, Class E - metabolism Statins Toxicity Type 2 diabetes
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