Stress-induced allodynia--evidence of increased pain sensitivity in healthy humans and patients with chronic pain after experimentally induced psychosocial stress
Experimental stress has been shown to have analgesic as well as allodynic effect in animals. Despite the obvious negative influence of stress in clinical pain conditions, stress-induced alteration of pain sensitivity has not been tested in humans so far. Therefore, we tested changes of pain sensitiv...
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| Veröffentlicht in: | PloS one 2013-08, Vol.8 (8), p.e69460-e69460 |
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| creator | Crettaz, Benjamin Marziniak, Martin Willeke, Peter Young, Peter Hellhammer, Dirk Stumpf, Astrid Burgmer, Markus |
| description | Experimental stress has been shown to have analgesic as well as allodynic effect in animals. Despite the obvious negative influence of stress in clinical pain conditions, stress-induced alteration of pain sensitivity has not been tested in humans so far. Therefore, we tested changes of pain sensitivity using an experimental stressor in ten female healthy subjects and 13 female patients with fibromyalgia.
Multiple sensory aspects of pain were evaluated in all participants with the help of the quantitative sensory testing protocol before (60 min) and after (10 and 90 min) inducing psychological stress with a standardized psychosocial stress test ("Trier Social Stress Test").
Both healthy subjects and patients with fibromyalgia showed stress-induced enhancement of pain sensitivity in response to thermal stimuli. However, only patients showed increased sensitivity in response to pressure pain.
Our results provide evidence for stress-induced allodynia/hyperalgesia in humans for the first time and suggest differential underlying mechanisms determining response to stressors in healthy subjects and patients suffering from chronic pain. Possible mechanisms of the interplay of stress and mediating factors (e.g. cytokines, cortisol) on pain sensitivity are mentioned. Future studies should help understand better how stress impacts on chronic pain conditions. |
| doi_str_mv | 10.1371/journal.pone.0069460 |
| format | Article |
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Multiple sensory aspects of pain were evaluated in all participants with the help of the quantitative sensory testing protocol before (60 min) and after (10 and 90 min) inducing psychological stress with a standardized psychosocial stress test ("Trier Social Stress Test").
Both healthy subjects and patients with fibromyalgia showed stress-induced enhancement of pain sensitivity in response to thermal stimuli. However, only patients showed increased sensitivity in response to pressure pain.
Our results provide evidence for stress-induced allodynia/hyperalgesia in humans for the first time and suggest differential underlying mechanisms determining response to stressors in healthy subjects and patients suffering from chronic pain. Possible mechanisms of the interplay of stress and mediating factors (e.g. cytokines, cortisol) on pain sensitivity are mentioned. Future studies should help understand better how stress impacts on chronic pain conditions.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0069460</identifier><identifier>PMID: 23950894</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Analgesics ; Animals ; Anxiety ; Biology ; Caffeine ; Chronic pain ; Chronic Pain - etiology ; Chronic Pain - physiopathology ; Cortisol ; Cytokines ; Female ; Fibromyalgia ; Fibromyalgia - physiopathology ; Hospitals ; Humans ; Hyperalgesia ; Hyperalgesia - etiology ; Hyperalgesia - physiopathology ; Kinases ; Medicine ; Middle Aged ; Muscle pain ; Pain ; Pain - etiology ; Pain - physiopathology ; Pain Measurement - methods ; Pain perception ; Pain sensitivity ; Pain Threshold - physiology ; Patients ; Physiology ; Psychological aspects ; Psychological stress ; Psychometrics ; Psychotherapy ; Rheumatology ; Sensitivity ; Sensitivity enhancement ; Sensory testing ; Social interactions ; Stress (Psychology) ; Stress, Psychological - complications ; Stress, Psychological - physiopathology ; Studies ; Thermal stimuli ; Young Adult</subject><ispartof>PloS one, 2013-08, Vol.8 (8), p.e69460-e69460</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Crettaz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Crettaz et al 2013 Crettaz et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-48f4d2360bdee4fa2e293a568010452a11f031bda558bf9cf5e30d533b1c09be3</citedby><cites>FETCH-LOGICAL-c692t-48f4d2360bdee4fa2e293a568010452a11f031bda558bf9cf5e30d533b1c09be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737255/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737255/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23950894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Paul, Friedemann</contributor><creatorcontrib>Crettaz, Benjamin</creatorcontrib><creatorcontrib>Marziniak, Martin</creatorcontrib><creatorcontrib>Willeke, Peter</creatorcontrib><creatorcontrib>Young, Peter</creatorcontrib><creatorcontrib>Hellhammer, Dirk</creatorcontrib><creatorcontrib>Stumpf, Astrid</creatorcontrib><creatorcontrib>Burgmer, Markus</creatorcontrib><title>Stress-induced allodynia--evidence of increased pain sensitivity in healthy humans and patients with chronic pain after experimentally induced psychosocial stress</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Experimental stress has been shown to have analgesic as well as allodynic effect in animals. Despite the obvious negative influence of stress in clinical pain conditions, stress-induced alteration of pain sensitivity has not been tested in humans so far. Therefore, we tested changes of pain sensitivity using an experimental stressor in ten female healthy subjects and 13 female patients with fibromyalgia.
Multiple sensory aspects of pain were evaluated in all participants with the help of the quantitative sensory testing protocol before (60 min) and after (10 and 90 min) inducing psychological stress with a standardized psychosocial stress test ("Trier Social Stress Test").
Both healthy subjects and patients with fibromyalgia showed stress-induced enhancement of pain sensitivity in response to thermal stimuli. However, only patients showed increased sensitivity in response to pressure pain.
Our results provide evidence for stress-induced allodynia/hyperalgesia in humans for the first time and suggest differential underlying mechanisms determining response to stressors in healthy subjects and patients suffering from chronic pain. Possible mechanisms of the interplay of stress and mediating factors (e.g. cytokines, cortisol) on pain sensitivity are mentioned. Future studies should help understand better how stress impacts on chronic pain conditions.</description><subject>Adult</subject><subject>Analgesics</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Biology</subject><subject>Caffeine</subject><subject>Chronic pain</subject><subject>Chronic Pain - etiology</subject><subject>Chronic Pain - physiopathology</subject><subject>Cortisol</subject><subject>Cytokines</subject><subject>Female</subject><subject>Fibromyalgia</subject><subject>Fibromyalgia - physiopathology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hyperalgesia</subject><subject>Hyperalgesia - etiology</subject><subject>Hyperalgesia - physiopathology</subject><subject>Kinases</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Muscle pain</subject><subject>Pain</subject><subject>Pain - etiology</subject><subject>Pain - physiopathology</subject><subject>Pain Measurement - methods</subject><subject>Pain perception</subject><subject>Pain sensitivity</subject><subject>Pain Threshold - physiology</subject><subject>Patients</subject><subject>Physiology</subject><subject>Psychological aspects</subject><subject>Psychological stress</subject><subject>Psychometrics</subject><subject>Psychotherapy</subject><subject>Rheumatology</subject><subject>Sensitivity</subject><subject>Sensitivity enhancement</subject><subject>Sensory testing</subject><subject>Social interactions</subject><subject>Stress (Psychology)</subject><subject>Stress, Psychological - complications</subject><subject>Stress, Psychological - physiopathology</subject><subject>Studies</subject><subject>Thermal stimuli</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLguhFx7RJ-nEjLIsfAwsLrnob0vR0miGT1CQdd_6Ov9R0212mshfSi5bked_35DQnil6maJXiIv2wNYPVXK16o2GFUF6RHD2KTtMKZ0meIfz46PskeubcFiGKyzx_Gp1kuKKorMhp9OfaW3AukboZBDQxV8o0By15ksBeNqAFxKaNpRYWuAtAz6WOHWgnvdxLfwhbcQdc-e4Qd8OOaxdzPWJegvYu_i19F4vOGi3FJOatBxvDTQ9W7gITIkeXKb93B9EZZ4TkKna3tT2PnrRcOXgxv8-iH58_fb_4mlxefVlfnF8mIq8yn5CyJU2Gc1Q3AKTlGWQV5jQvUYoIzXiatgindcMpLeu2Ei0FjBqKcZ0KVNWAz6LXk2-vjGNzex1LCUYZJbgkgVhPRGP4lvWhfG4PzHDJbheM3TBuvRQKmGgEzQXGoiyBFDSvUC04FGTMK0lOg9fHOW2od9CI0AjL1cJ0uaNlxzZmz3CBi4yOBu9mA2t-DeA820knQCmuwQxj3VmO0qpEKKBv_kEfPt1MbXg4gNStCbliNGXnpCgJIlk5xq4eoMLTwE6KcBdbGdYXgvcLQWA83PgNH5xj6-tv_89e_Vyyb4_Y6Qo6owYvjXZLkEygsMY5C-19k1PExlG66wYbR4nNoxRkr45_0L3obnbwXz4XHSw</recordid><startdate>20130807</startdate><enddate>20130807</enddate><creator>Crettaz, Benjamin</creator><creator>Marziniak, Martin</creator><creator>Willeke, Peter</creator><creator>Young, Peter</creator><creator>Hellhammer, Dirk</creator><creator>Stumpf, Astrid</creator><creator>Burgmer, Markus</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130807</creationdate><title>Stress-induced allodynia--evidence of increased pain sensitivity in healthy humans and patients with chronic pain after experimentally induced psychosocial stress</title><author>Crettaz, Benjamin ; Marziniak, Martin ; Willeke, Peter ; Young, Peter ; Hellhammer, Dirk ; Stumpf, Astrid ; Burgmer, Markus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-48f4d2360bdee4fa2e293a568010452a11f031bda558bf9cf5e30d533b1c09be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Analgesics</topic><topic>Animals</topic><topic>Anxiety</topic><topic>Biology</topic><topic>Caffeine</topic><topic>Chronic pain</topic><topic>Chronic Pain - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crettaz, Benjamin</au><au>Marziniak, Martin</au><au>Willeke, Peter</au><au>Young, Peter</au><au>Hellhammer, Dirk</au><au>Stumpf, Astrid</au><au>Burgmer, Markus</au><au>Paul, Friedemann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stress-induced allodynia--evidence of increased pain sensitivity in healthy humans and patients with chronic pain after experimentally induced psychosocial stress</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-08-07</date><risdate>2013</risdate><volume>8</volume><issue>8</issue><spage>e69460</spage><epage>e69460</epage><pages>e69460-e69460</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Experimental stress has been shown to have analgesic as well as allodynic effect in animals. Despite the obvious negative influence of stress in clinical pain conditions, stress-induced alteration of pain sensitivity has not been tested in humans so far. Therefore, we tested changes of pain sensitivity using an experimental stressor in ten female healthy subjects and 13 female patients with fibromyalgia.
Multiple sensory aspects of pain were evaluated in all participants with the help of the quantitative sensory testing protocol before (60 min) and after (10 and 90 min) inducing psychological stress with a standardized psychosocial stress test ("Trier Social Stress Test").
Both healthy subjects and patients with fibromyalgia showed stress-induced enhancement of pain sensitivity in response to thermal stimuli. However, only patients showed increased sensitivity in response to pressure pain.
Our results provide evidence for stress-induced allodynia/hyperalgesia in humans for the first time and suggest differential underlying mechanisms determining response to stressors in healthy subjects and patients suffering from chronic pain. Possible mechanisms of the interplay of stress and mediating factors (e.g. cytokines, cortisol) on pain sensitivity are mentioned. Future studies should help understand better how stress impacts on chronic pain conditions.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23950894</pmid><doi>10.1371/journal.pone.0069460</doi><tpages>e69460</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Analgesics Animals Anxiety Biology Caffeine Chronic pain Chronic Pain - etiology Chronic Pain - physiopathology Cortisol Cytokines Female Fibromyalgia Fibromyalgia - physiopathology Hospitals Humans Hyperalgesia Hyperalgesia - etiology Hyperalgesia - physiopathology Kinases Medicine Middle Aged Muscle pain Pain Pain - etiology Pain - physiopathology Pain Measurement - methods Pain perception Pain sensitivity Pain Threshold - physiology Patients Physiology Psychological aspects Psychological stress Psychometrics Psychotherapy Rheumatology Sensitivity Sensitivity enhancement Sensory testing Social interactions Stress (Psychology) Stress, Psychological - complications Stress, Psychological - physiopathology Studies Thermal stimuli Young Adult |
| title | Stress-induced allodynia--evidence of increased pain sensitivity in healthy humans and patients with chronic pain after experimentally induced psychosocial stress |
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