O-antigen protects gram-negative bacteria from histone killing
Beyond their traditional role of wrapping DNA, histones display antibacterial activity to Gram-negative and -positive bacteria. To identify bacterial components that allow survival to a histone challenge, we selected resistant bacteria from homologous Escherichia coli libraries that harbor plasmids...
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| Veröffentlicht in: | PloS one 2013-08, Vol.8 (8), p.e71097-e71097 |
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| creator | Chaput, Catherine Spindler, Eileen Gill, Ryan T Zychlinsky, Arturo |
| description | Beyond their traditional role of wrapping DNA, histones display antibacterial activity to Gram-negative and -positive bacteria. To identify bacterial components that allow survival to a histone challenge, we selected resistant bacteria from homologous Escherichia coli libraries that harbor plasmids carrying pieces of the chromosome in different sizes. We identified genes required for exopolysaccharide production and for the synthesis of the polysaccharide domain of the lipopolysaccharide, called O-antigen. Indeed, O-antigen and exopolysaccharide conferred further resistance to histones. Notably, O-antigen also conferred resistance to histones in the pathogens Shigella flexneri and Klebsiella pneumoniae. |
| doi_str_mv | 10.1371/journal.pone.0071097 |
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To identify bacterial components that allow survival to a histone challenge, we selected resistant bacteria from homologous Escherichia coli libraries that harbor plasmids carrying pieces of the chromosome in different sizes. We identified genes required for exopolysaccharide production and for the synthesis of the polysaccharide domain of the lipopolysaccharide, called O-antigen. Indeed, O-antigen and exopolysaccharide conferred further resistance to histones. Notably, O-antigen also conferred resistance to histones in the pathogens Shigella flexneri and Klebsiella pneumoniae.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0071097</identifier><identifier>PMID: 23951089</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Antibacterial activity ; Antigens ; Antimicrobial agents ; Bacteria ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Bioengineering ; Biology ; Data analysis ; Deoxyribonucleic acid ; DNA ; DNA binding proteins ; E coli ; Escherichia coli ; Escherichia coli - physiology ; Gene Expression Regulation, Bacterial ; Genes, Bacterial ; Gram-negative bacteria ; Gram-Negative Bacterial Infections - metabolism ; Gram-Negative Bacterial Infections - microbiology ; Histones ; Histones - metabolism ; Homology ; Host-Pathogen Interactions ; Humans ; Klebsiella ; Klebsiella pneumoniae ; Klebsiella pneumoniae - physiology ; Lipopolysaccharides ; Medical screening ; Microbial drug resistance ; Mitogens ; Neutrophils ; O Antigens - genetics ; O Antigens - metabolism ; Peptides ; Plasmids ; Polysaccharides ; Polysaccharides - genetics ; Polysaccharides - metabolism ; Shigella ; Shigella flexneri - physiology ; Signal Transduction ; Staphylococcus aureus</subject><ispartof>PloS one, 2013-08, Vol.8 (8), p.e71097-e71097</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Chaput et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chaput, Catherine</au><au>Spindler, Eileen</au><au>Gill, Ryan T</au><au>Zychlinsky, Arturo</au><au>Kaufmann, Gunnar F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>O-antigen protects gram-negative bacteria from histone killing</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-08-08</date><risdate>2013</risdate><volume>8</volume><issue>8</issue><spage>e71097</spage><epage>e71097</epage><pages>e71097-e71097</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Beyond their traditional role of wrapping DNA, histones display antibacterial activity to Gram-negative and -positive bacteria. To identify bacterial components that allow survival to a histone challenge, we selected resistant bacteria from homologous Escherichia coli libraries that harbor plasmids carrying pieces of the chromosome in different sizes. We identified genes required for exopolysaccharide production and for the synthesis of the polysaccharide domain of the lipopolysaccharide, called O-antigen. Indeed, O-antigen and exopolysaccharide conferred further resistance to histones. Notably, O-antigen also conferred resistance to histones in the pathogens Shigella flexneri and Klebsiella pneumoniae.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23951089</pmid><doi>10.1371/journal.pone.0071097</doi><tpages>e71097</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antibacterial activity Antigens Antimicrobial agents Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Bioengineering Biology Data analysis Deoxyribonucleic acid DNA DNA binding proteins E coli Escherichia coli Escherichia coli - physiology Gene Expression Regulation, Bacterial Genes, Bacterial Gram-negative bacteria Gram-Negative Bacterial Infections - metabolism Gram-Negative Bacterial Infections - microbiology Histones Histones - metabolism Homology Host-Pathogen Interactions Humans Klebsiella Klebsiella pneumoniae Klebsiella pneumoniae - physiology Lipopolysaccharides Medical screening Microbial drug resistance Mitogens Neutrophils O Antigens - genetics O Antigens - metabolism Peptides Plasmids Polysaccharides Polysaccharides - genetics Polysaccharides - metabolism Shigella Shigella flexneri - physiology Signal Transduction Staphylococcus aureus |
| title | O-antigen protects gram-negative bacteria from histone killing |
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