CD200R/CD200 inhibits osteoclastogenesis: new mechanism of osteoclast control by mesenchymal stem cells in human

Bone homeostasis is maintained by the balance between bone-forming osteoblasts and bone-degrading osteoclasts. Osteoblasts have a mesenchymal origin whereas osteoclasts belong to the myeloid lineage. Osteoclast and osteoblast communication occurs through soluble factors secretion, cell-bone interact...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e72831-e72831
Hauptverfasser:	Varin, Audrey, Pontikoglou, Charalampos, Labat, Elodie, Deschaseaux, Frédéric, Sensebé, Luc
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - pharmacology Antigens, CD - physiology Antigens, Surface - physiology Arthritis Biocompatibility Biomedical materials Bone diseases Bone marrow Bone resorption Bone Resorption - genetics Bone surgery Bone turnover CD200 antigen Cell Differentiation - drug effects Cell Differentiation - genetics Cell interactions Cells, Cultured Cytokines Down-Regulation - genetics Gene expression Homeostasis Humans Kinases Lymphocytes Macrophage Colony-Stimulating Factor - pharmacology Macrophages MAP Kinase Signaling System - drug effects Mesenchymal stem cells Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - physiology Mesenchyme Monocytes Monocytes - drug effects Monocytes - physiology Myeloid cells NF-AT protein Osteoblasts Osteoclastogenesis Osteoclasts Osteoclasts - drug effects Osteoclasts - physiology Osteoprogenitor cells Phosphatase RANK Ligand - pharmacology Receptors, Cell Surface - physiology Recombinant Proteins - pharmacology Regulation Signal transduction Signaling Stem cells T cells TRANCE protein Transcription factors Tumor necrosis factor-TNF
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