Human voltage-gated proton channel hv1: a new potential biomarker for diagnosis and prognosis of colorectal cancer

Solid tumors exist in a hypoxic microenvironment, and possess high-glycolytic metabolites. To avoid the acidosis, tumor cells must exhibit a dynamic cytosolic pH regulation mechanism(s). The voltage-gated proton channel Hv1 mediates NADPH oxidase function by compensating cellular loss of electrons w...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e70550-e70550
Hauptverfasser:	Wang, Yifan, Wu, Xingye, Li, Qiang, Zhang, Shangrong, Li, Shu Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Acidosis Adult Aged Antineoplastic drugs Antitumor agents Apoptosis Bioindicators Biology Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biophysics Biotechnology Blotting, Western Breast cancer Cancer Cancer metastasis Cell Line Cell migration Cell Movement - genetics Cell Movement - physiology Chemotherapy Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Diagnosis Drugs Electric potential Ethics Extrusion Female Fluorescent Antibody Technique Gastrointestinal diseases Glycolysis Health aspects Humans Hydrogen-Ion Concentration Hypoxia Immunocytochemistry Immunohistochemistry Ion Channels - genetics Ion Channels - metabolism Lymph nodes Male Medical diagnosis Medical prognosis Medicine Metabolites Metastases Metastasis Middle Aged NAD(P)H oxidase Neutrophils Oxidases p53 Protein Pathology Patients pH effects Physics Polyclonal antibodies Polymerase chain reaction Polyps Prognosis Proteins Protons Real-Time Polymerase Chain Reaction Ribonucleic acid RNA Rodents siRNA Solid tumors Surgery Tissues Tumor cell lines Tumor cells Tumor proteins Tumors Voltage
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