Comparative gene expression profiling identifies common molecular signatures of NF-κB activation in canine and human diffuse large B cell lymphoma (DLBCL)

We present the first comparison of global transcriptional changes in canine and human diffuse large B-cell lymphoma (DLBCL), with particular reference to the nuclear factor-kappa B (NF-κB) pathway. Microarray data generated from canine DLBCL and normal lymph nodes were used for differential expressi...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e72591-e72591
Hauptverfasser:	Mudaliar, Manikhandan A V, Haggart, Ross D, Miele, Gino, Sellar, Grant, Tan, Karen A L, Goodlad, John R, Milne, Elspeth, Vail, David M, Kurzman, Ilene, Crowther, Daniel, Argyle, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-cell lymphoma Blotting, Western Cancer Cell activation Comparative analysis Data processing Datasets DNA microarrays Dogs Electrophoretic Mobility Shift Assay Gene expression Gene mapping Genes Genetic aspects Humans Immunohistochemistry Kinases Lymph nodes Lymphocytes B Lymphoma Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - metabolism NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein Non-Hodgkin's lymphomas Oligonucleotide Array Sequence Analysis Principal components analysis Tissue Array Analysis Transcription Transcriptome Veterinary colleges
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