Hydronephrotic urine in the obstructed kidney promotes urothelial carcinoma cell proliferation, migration, invasion through the activation of mTORC2-AKT and ERK signaling pathways

Obstructive nephropathy is the most common presentation of urothelial carcinoma. The role of the urine in the obstructed kidney namely "hydronephrotic urine" in urothelial carcinoma has not been extensively explored. This study aims to evaluate whether hydronephrotic urine in the obstructe...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e74300
Hauptverfasser:	Chang, Chi-Hao, Li, Jian-Ri, Shu, Kuo-Hsiung, Fu, Yun-Ching, Wu, Ming-Ju
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation AKT protein Animal models Animals Bladder cancer Cancer therapies Carcinoma Cell Line, Tumor Cell migration Cell Movement - drug effects Cell Proliferation Cell survival Cell Survival - drug effects Clinical medicine Cyclin-dependent kinase 2 Cytokines Epidermal growth factor Epidermal Growth Factor - pharmacology Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Fibroblast growth factors Gene Expression Regulation, Neoplastic - drug effects Growth factors Hydronephrosis - therapy Hydronephrosis - urine Interferon Kidney diseases Kidneys Kinases Laboratory animals Male Mechanistic Target of Rapamycin Complex 2 Medicine Metastases Metastasis Motility Multiprotein Complexes - metabolism Neoplasm Invasiveness Neovascularization, Pathologic Nephrology Nephropathy Platelet-derived growth factor Platelet-derived growth factor BB Protein arrays Proteins Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Rodents Signal transduction Signal Transduction - drug effects Signaling TOR Serine-Threonine Kinases - metabolism Urine Urogenital system Urologic Neoplasms - blood supply Urologic Neoplasms - pathology Urothelial carcinoma Urothelium - pathology Vascular endothelial growth factor γ-Interferon
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