Aquaporin-4 inhibition mediates piroxicam-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rodents

Aquaporin-4(AQP4) is an abundant water channel protein in brain that regulates water transport to maintain homeostasis. Cerebral edema resulting from AQP4 over expression is considered to be one of the major determinants for progressive neuronal insult during cerebral ischemia. Although, both upregu...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e73481
Hauptverfasser:	Bhattacharya, Pallab, Pandey, Anand Kumar, Paul, Sudip, Patnaik, Ranjana, Yavagal, Dileep R
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal cognition Animals Aquaporin 4 Aquaporin 4 - antagonists & inhibitors Aquaporin 4 - genetics Aquaporin 4 - metabolism Aquaporins Biochemical analysis Biomedical engineering Brain Brain - drug effects Brain - metabolism Brain Edema - complications Brain Infarction - complications Brain Ischemia - complications Calcium Calcium (intracellular) Calcium - metabolism Cerebral infarction Cytotoxicity Dose-Response Relationship, Drug Edema Energy value Engineering Force and energy Free radicals Homeopathy Homeostasis Inhibition Ischemia Kinases Male Malondialdehyde Malondialdehyde - metabolism Materia medica and therapeutics Moisture content Neurological diseases Neurons Neuroprotection Neuroprotective Agents - pharmacology Nitrites - metabolism Pathology Piroxicam Piroxicam - pharmacology Polymerase chain reaction Rats Reduction Reperfusion Reperfusion Injury - complications Reperfusion Injury - metabolism Reperfusion Injury - prevention & control Rodents Rotarod Performance Test Size estimation Stroke Stroke - complications Studies Therapeutics Traumatic brain injury Veins & arteries Water content Water transport
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