HIV-1 tropism testing in subjects achieving undetectable HIV-1 RNA: diagnostic accuracy, viral evolution and compartmentalization

Technically, HIV-1 tropism can be evaluated in plasma or peripheral blood mononuclear cells (PBMCs). However, only tropism testing of plasma HIV-1 has been validated as a tool to predict virological response to CCR5 antagonists in clinical trials. The preferable tropism testing strategy in subjects...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e67085-e67085
Hauptverfasser:	Pou, Christian, Codoñer, Francisco M, Thielen, Alexander, Bellido, Rocío, Pérez-Álvarez, Susana, Cabrera, Cecilia, Dalmau, Judith, Curriu, Marta, Lie, Yolanda, Noguera-Julian, Marc, Puig, Jordi, Martínez-Picado, Javier, Blanco, Julià, Coakley, Eoin, Däumer, Martin, Clotet, Bonaventura, Paredes, Roger
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult AIDS Amino Acid Sequence Antiretroviral agents Assaying Biological effects Biological evolution Biology Care and treatment CCR5 protein Clinical decision making Clinical trials Compartments CXCR4 protein Decision making Deoxyribonucleic acid Diagnostic systems DNA DNA identification Dosage and administration Drug therapy Evolution Evolution, Molecular Feasibility studies Female Genotype Glycoprotein gp120 HIV HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - metabolism HIV Infections - blood HIV Infections - diagnosis HIV Infections - metabolism HIV Infections - virology HIV tests HIV-1 - genetics HIV-1 - metabolism HIV-1 - physiology Human immunodeficiency virus Humans Leukocytes (mononuclear) Male Medical diagnosis Medical research Medicine Middle Aged Molecular Sequence Data Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Peripheral blood mononuclear cells Phenotype Plasma Population Receptors, CXCR4 - metabolism Retrospective Studies Ribonucleic acid RNA RNA, Viral - blood Sensitivity Sensitivity and Specificity Sensitivity enhancement Studies Time Factors Tropism Viral Tropism Viremia Viruses
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Zusammenfassung:	Technically, HIV-1 tropism can be evaluated in plasma or peripheral blood mononuclear cells (PBMCs). However, only tropism testing of plasma HIV-1 has been validated as a tool to predict virological response to CCR5 antagonists in clinical trials. The preferable tropism testing strategy in subjects with undetectable HIV-1 viremia, in whom plasma tropism testing is not feasible, remains uncertain. We designed a proof-of-concept study including 30 chronically HIV-1-infected individuals who achieved HIV-1 RNA
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0067085