Upregulated microRNA-92b regulates the differentiation and proliferation of EpCAM-positive fetal liver cells by targeting C/EBPß

microRNAs (miRNAs) are short noncoding RNAs that negatively regulate gene expression. Although recent evidences have been indicated that their aberrant expression may play an important role in cancer stem cells, the mechanism of their deregulation in neoplastic transformation of liver cancer stem ce...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e68004
Hauptverfasser:	Qian, Nian-Song, Liu, Wei-Hui, Lv, Wen-Ping, Xiang, Xin, Su, Ming, Raut, Vikram, Chen, Yong-Liang, Dong, Jia-Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Analysis Animals Antigens, Neoplasm - genetics Antigens, Neoplasm - metabolism Biology Cancer Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology CCAAT-Enhancer-Binding Protein-beta - genetics CCAAT-Enhancer-Binding Protein-beta - metabolism Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cell cycle Cell growth Cell Proliferation Cells, Cultured Correlation analysis Deregulation Differentiation DNA microarrays Drinking water Epithelial Cell Adhesion Molecule Fetus - cytology Fetus - metabolism Fetuses Flow cytometry Function analysis Gene expression Gene Expression Profiling Genes Genetic transformation Hepatocytes Hepatocytes - cytology Hepatocytes - metabolism Humans Hypotheses In vivo methods and tests Laboratory animals Liver Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver transplants Male Medicine MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Oligonucleotide Array Sequence Analysis Polymerase chain reaction Rats Rats, Inbred F344 Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA Rodents Signal transduction Stem cells Surgery Transformation Up-Regulation
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