Adult hippocampal neurogenesis and mRNA expression are altered by perinatal arsenic exposure in mice and restored by brief exposure to enrichment

Arsenic is a common and pervasive environmental contaminant found in drinking water in varying concentrations depending on region. Exposure to arsenic induces behavioral and cognitive deficits in both human populations and in rodent models. The Environmental Protection Agency (EPA) standard for the...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e73720
Hauptverfasser:	Tyler, Christina R, Allan, Andrea M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Animal behavior Animal cognition Animal models Animals Apoptosis Arsenic Arsenic - toxicity Axonogenesis Brain Brain research Carcinogens Cell cycle Cell Proliferation Cells (biology) Cognitive ability Contaminants Dentate gyrus Differentiation DNA methylation Drinking water Drug dosages Enrichment Environment models Environmental protection Exposure Female Gene expression Gene Expression Regulation - drug effects Hippocampus Hippocampus - drug effects Hippocampus - growth & development Hippocampus - metabolism Human behavior Human populations Learning Memory Messenger RNA Mice Mice, Inbred C57BL Microscopy, Confocal Neural stem cells Neurogenesis Neurogenesis - drug effects Neurosciences Notch protein Perinatal exposure Pregnancy Prenatal Exposure Delayed Effects Real-Time Polymerase Chain Reaction RNA, Messenger - genetics Rodents Signaling Transcription factors Water pollution
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