Expression of legumain correlates with prognosis and metastasis in gastric carcinoma

Legumain, a novel asparaginyl endopeptidase, has been observed to be highly expressed in several types of tumors, which may play a vital role in carcinogenesis. However, there is no study investigating the relationship among Legumain expression, clinicopathologic, biological variables and patient pr...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e73090
Hauptverfasser:	Guo, Pengtao, Zhu, Zhi, Sun, Zhe, Wang, Zhenning, Zheng, Xinyu, Xu, Huimian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Angiogenesis Biomarkers Breast cancer Cancer Carcinogenesis Carcinogens Cell growth Committees Cysteine Endopeptidases - genetics Cysteine Endopeptidases - metabolism Development and progression Endopeptidase Endopeptidases Extracellular matrix Female Gastric cancer Gastric mucosa Gastric Mucosa - metabolism Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Humans Immunohistochemistry Kinases Legumain Lymph nodes Lymphatic Metastasis Lymphatic system Male Medical prognosis Metastases Metastasis Middle Aged Oncology Patients Physiological aspects Prognosis Prostate Stomach cancer Stomach Neoplasms - diagnosis Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Surgery Survival Survival Analysis Tumors Young Adult
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