Pivotal role of matrix metalloproteinase 13 in extracellular matrix turnover in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by excessive deposition of extracellular matrix (ECM). We investigated the regulation of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in lung fibrosis. MMP and TIMP expression, collagenolytic activity and collagen...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e73279
Hauptverfasser:	Nkyimbeng, Takwi, Ruppert, Clemens, Shiomi, Takayuki, Dahal, Bhola, Lang, György, Seeger, Werner, Okada, Yasunori, D'Armiento, Jeanine, Günther, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Bleomycin Bleomycin - pharmacology Case-Control Studies Collagen Collagen - metabolism Collagenase 3 Cysts Deposition Development and progression Extracellular matrix Extracellular Matrix - drug effects Extracellular Matrix - metabolism Fibrosis Gene expression Genetic aspects Honeycomb construction Hospitals Humans Hydroxyproline - metabolism Idiopathic Pulmonary Fibrosis - chemically induced Idiopathic Pulmonary Fibrosis - enzymology Idiopathic Pulmonary Fibrosis - metabolism Idiopathic Pulmonary Fibrosis - pathology Inflammation Inflammatory response Lung - drug effects Lung - enzymology Lung - pathology Lung diseases Lungs Matrix metalloproteinase Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 1 - metabolism Matrix Metalloproteinase 13 - deficiency Matrix Metalloproteinase 13 - genetics Matrix Metalloproteinase 13 - metabolism Matrix metalloproteinases Medicine Metalloproteinase Mice Middle Aged Monoclonal antibodies Neutrophil collagenase Nitrogen Pathogenesis Physiological aspects Pneumonia Proteases Proteolysis - drug effects Pulmonary fibrosis Rodents Surgeons Thoracic surgery Tissue Donors Tissue inhibitor of metalloproteinases Tissue Inhibitor of Metalloproteinases - metabolism Up-Regulation - drug effects
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