Mapping of Mcs30, a new mammary carcinoma susceptibility quantitative trait locus (QTL30) on rat chromosome 12: identification of fry as a candidate Mcs gene

Rat strains differ dramatically in their susceptibility to mammary carcinogenesis. On the assumption that susceptibility genes are conserved across mammalian species and hence inform human carcinogenesis, numerous investigators have used genetic linkage studies in rats to identify genes responsible...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e70930
Hauptverfasser:	Ren, Xuefeng, Graham, Jessica C, Jing, Lichen, Mikheev, Andrei M, Gao, Yuan, Lew, Jenny Pan, Xie, Hong, Kim, Andrea S, Shang, Xiuling, Friedman, Cynthia, Vail, Graham, Fang, Ming Zhu, Bromberg, Yana, Zarbl, Helmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Animals Blotting, Northern Breast cancer Breast carcinoma Cancer therapies Carcinogenesis Carcinogens Carcinoma Cell Line, Tumor Cells, Cultured Chromosome 12 Chromosome 13 Chromosomes Conserved sequence Dentistry Deoxyribonucleic acid Disease susceptibility DNA Drosophila Environmental health Evolutionary conservation Female Females Gene expression Gene mapping Genes Genetic aspects Genetic Predisposition to Disease - genetics Genotype Health sciences Humans In Situ Hybridization, Fluorescence Insects Kinases Laboratory animals Loci Lymphatic system Male Mammary gland Mammary Neoplasms, Animal - genetics Medical research mRNA Mutation Nucleotide sequence Occupational health Phenotype Phosphorylation Physiological aspects Polymerase Chain Reaction Preventive medicine Proteins - genetics Proteins - metabolism Quantitative trait loci Quantitative Trait Loci - genetics Rats Rats, Inbred F344 Risk factors Single nucleotide polymorphisms Single-nucleotide polymorphism Synteny Toxicology Tumor cell lines Tumors
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