Unique association between global DNA hypomethylation and chromosomal alterations in human hepatocellular carcinoma

Global DNA hypomethylation is a characteristic feature of cancer cells that closely associates with chromosomal instability (CIN). However, the association between these characteristics during hepatocarcinogenesis remains unclear. Herein, we determined the relationship between hypomethylation and CI...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e72312
Hauptverfasser:	Nishida, Naoshi, Kudo, Masatoshi, Nishimura, Takafumi, Arizumi, Tadaaki, Takita, Masahiro, Kitai, Satoshi, Yada, Norihisa, Hagiwara, Satoru, Inoue, Tatsuo, Minami, Yasunori, Ueshima, Kazuomi, Sakurai, Toshiharu, Yokomichi, Naosuke, Nagasaka, Takeshi, Goel, Ajay
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analysis Biology Bisulfite Carcinogenesis Carcinogens Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - genetics Cell adhesion & migration Chromosome Aberrations Chromosomes Cirrhosis CpG islands Dentistry Deoxyribonucleic acid Development and progression DNA DNA methylation DNA Methylation - genetics Female Gastroenterology Gene sequencing Genetic aspects Genetic markers Genomic instability Hepatitis Hepatitis C Hepatocellular carcinoma Hepatology Humans In Vitro Techniques Liver Liver - metabolism Liver - pathology Liver cancer Liver cirrhosis Liver Neoplasms - epidemiology Liver Neoplasms - genetics Male Medicine Metastasis Methylation Microsatellites Middle Aged Nucleotide sequence Oncology Pathogenesis Pharmaceutical sciences Physiological aspects Stability Surgery Tissues Tumor suppressor genes Tumors University faculty University graduates Viruses
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