Vaccination directed against the human endogenous retrovirus-K envelope protein inhibits tumor growth in a murine model system

Human endogenous retrovirus (HERV) genomes are chromosomally integrated in all cells of an individual. They are normally transcriptionally silenced and transmitted only vertically. Enhanced expression of HERV-K accompanied by the emergence of anti-HERV-K-directed immune responses has been observed i...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e72756-e72756
Hauptverfasser:	Kraus, Benjamin, Fischer, Katrin, Büchner, Sarah M, Wels, Winfried S, Löwer, Roswitha, Sliva, Katja, Schnierle, Barbara S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antigens Biology Blotting, Western Chickens Cytotoxicity, Immunologic Disease Disease Models, Animal E coli Endogenous Retroviruses - metabolism Env gene Env protein Female Galactosidase Gene expression Genomes Genomics Glycoproteins Glycoproteins - metabolism HEK293 Cells HIV Human immunodeficiency virus Humans Immune response Immunity, Cellular Immunization Immunological tolerance Immunology Immunotherapy Infections Intravenous administration Kidney cancer Lung cancer Lung Neoplasms - pathology Lung Neoplasms - secondary Lung nodules Lymphocytes Medicine Melanoma Metastases Mice Neoplasms - immunology Neoplasms - pathology Neoplasms - prevention & control Nodules Ovarian cancer Protein expression Proteins Public health Renal cell carcinoma Splenocytes T-Lymphocytes, Cytotoxic - immunology Transcription Tumors Vaccination Vaccine development Vaccines Vaccinia virus - genetics Viral envelope proteins Viral Envelope Proteins - immunology Viral infections Viruses β-Galactosidase
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