No evidence for selection of HIV-1 with enhanced gag-protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial

Use of antiretroviral-based microbicides for HIV-1 prophylaxis could introduce a transmission barrier that inadvertently facilitates the selection of fitter viral variants among incident infections. To investigate this, we assessed the in vitro function of gag-protease and nef sequences from partici...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e71758-e71758
Hauptverfasser:	Chopera, Denis R, Mann, Jaclyn K, Mwimanzi, Philip, Omarjee, Saleha, Kuang, Xiaomei T, Ndabambi, Nonkululeko, Goodier, Sarah, Martin, Eric, Naranbhai, Vivek, Karim, Salim Abdool, Karim, Quarraisha Abdool, Brumme, Zabrina L, Ndung'u, Thumbi, Williamson, Carolyn, Brockman, Mark A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adenine - administration & dosage Adenine - analogs & derivatives Adenine - pharmacology AIDS Anti-HIV Agents - administration & dosage Anti-HIV Agents - pharmacology Antiretroviral agents Antiretroviral drugs Clinical Trials as Topic Clustering Disease prevention Female Fitness gag Gene Products, Human Immunodeficiency Virus - genetics Gene sequencing Health sciences HIV HIV Infections - prevention & control HIV Infections - transmission HIV Infections - virology HIV-1 - drug effects HIV-1 - enzymology HIV-1 - genetics Human immunodeficiency virus Humans Hypothesis testing Infections Infectious diseases Laboratories Medical research Medicine Microbicides nef Gene Products, Human Immunodeficiency Virus - genetics Nef protein Organophosphonates - administration & dosage Organophosphonates - pharmacology Pathogenesis Phylogeny Prophylaxis Protease Proteinase Sequence Analysis, DNA Tenofovir Tuberculosis Vaginal Creams, Foams, and Jellies - administration & dosage Vaginal Creams, Foams, and Jellies - pharmacology Virology Virus Replication Viruses
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