Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model

Human metapneumovirus (hMPV) infection causes acute respiratory tract infections (RTI) which can result in hospitalization of both children and adults. To date, no antiviral or vaccine is available for this common viral infection. Immunomodulators could represent an interesting strategy for the trea...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e72529
Hauptverfasser:	Aerts, Laetitia, Hamelin, Marie-Ève, Rhéaume, Chantal, Lavigne, Sophie, Couture, Christian, Kim, Woojin, Susan-Resiga, Delia, Prat, Annik, Seidah, Nabil G, Vergnolle, Nathalie, Riteau, Beatrice, Boivin, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Airway management Animals Children Chlorocebus aethiops Coagulation COS Cells Cytokines Cytokines - biosynthesis Cytokines - genetics Disease Disease Models, Animal Furin Furin - genetics Furin - metabolism Fusion protein Gene Expression Regulation - genetics HEK293 Cells Humans Immune system Immunomodulation Immunomodulators Infections Infectivity Inflammation Influenza Interleukin 6 Intranasal administration Laboratories Life Sciences Lungs Metapneumovirus - metabolism Mice Mice, Inbred BALB C Monocyte chemoattractant protein 1 Paramyxoviridae Infections - genetics Paramyxoviridae Infections - metabolism Paramyxoviridae Infections - pathology Pathogenesis Physiology Protease Proteinase Proteins Receptor, PAR-1 - agonists Receptor, PAR-1 - genetics Receptor, PAR-1 - metabolism Receptors Respiratory diseases Respiratory tract Respiratory tract diseases Respiratory Tract Infections - genetics Respiratory Tract Infections - metabolism Respiratory Tract Infections - pathology RNA polymerase Rodents Severity of Illness Index Studies Viral infections Viruses Weight loss Weight reduction
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