Topical gene electrotransfer to the epidermis of hairless guinea pig by non-invasive multielectrode array

Topical gene delivery to the epidermis has the potential to be an effective therapy for skin disorders, cutaneous cancers, vaccinations and systemic metabolic diseases. Previously, we reported on a non-invasive multielectrode array (MEA) that efficiently delivered plasmid DNA and enhanced expression...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e73423-e73423
Hauptverfasser:	Guo, Siqi, Israel, Annelise L, Basu, Gaurav, Donate, Amy, Heller, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Animal models Animals Biology Coagulation factors Deoxyribonucleic acid Disorders DNA Drinking water Electrodes Electroporation - methods Engineering Epidermis Epidermis - metabolism Epidermis - pathology Factor IX - biosynthesis Factor IX - genetics Feasibility studies Female Gene expression Gene therapy Gene transfer Gene Transfer Techniques Guinea Pigs Hairless Hemophilia Histology Humans Keratin Low level Mathematics Medicine Metabolic disorders Microscopy Plasmids Plasmids - pharmacology Skin diseases Skin Neoplasms - genetics Skin Neoplasms - therapy Time Factors
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