Increased systemic Th17 cytokines are associated with diastolic dysfunction in children and adolescents with diabetic ketoacidosis

Diastolic dysfunction suggestive of diabetic cardiomyopathy is established in children with T1DM, but its pathogenesis is not well understood. We studied the relationships of systemic inflammatory cytokines/chemokines and cardiac function in 17 children with T1DM during and after correction of diabe...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e71905-e71905
Hauptverfasser:	Hoffman, William H, Passmore, Gregory G, Hannon, David W, Talor, Monica V, Fox, Pam, Brailer, Catherine, Haislip, Dynita, Keel, Cynthia, Harris, Glenn, Rose, Noel R, Fiordalisi, Irma, Čiháková, Daniela
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adolescents Blood pressure Cardiomyopathy Chemokines Child Children Critical care Cytokines Cytokines - blood Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - physiopathology Diabetic ketoacidosis Diabetic Ketoacidosis - blood Diabetic Ketoacidosis - immunology Diabetic Ketoacidosis - physiopathology Diastole Edema Electrolytes Endocrinology Female Granulocyte colony-stimulating factor Granulocyte-macrophage colony-stimulating factor Heart diseases Helper cells Humans Hyperglycemia Hypertension - blood Hypertension - etiology Hypertension - immunology Inflammation Inflammation Mediators - blood Inflammatory response Insulin resistance Interleukin 12 Interleukin 17 Ketoacidosis Lymphocytes T Male Medicine Metabolism Metabolites Neurosciences Oxidation Pathogenesis Pathology Patients Pediatrics Teenagers Th17 Cells - immunology Th17 Cells - metabolism Ventricular Dysfunction, Left - blood Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - immunology
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