HER2 as a promising target for cytotoxicity T cells in human melanoma therapy

Anti-HER2/neu antibody therapy has been reported to mediate tumor regression of HER2/ neu(+) tumors. Here we demonstrated the expression of HER2 in a wide range of human melanoma cells including a primary culture and seven cell lines, and we further investigated whether HER2 could be served as a tar...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e73261
Hauptverfasser:	Ma, Juan, Han, Huamin, Liu, Deruo, Li, Wei, Feng, Hongxiang, Xue, Xin, Wu, Xiaoran, Niu, Ge, Zhang, Ge, Zhao, Yunfeng, Liu, Changzhen, Tao, Hua, Gao, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bispecific - immunology Antibodies, Bispecific - pharmacology Antibodies, Neoplasm - immunology Antibodies, Neoplasm - pharmacology Anticancer properties Biophysics Bispecific antibodies Breast cancer Cancer therapies CD3 antigen CD3 Complex - immunology CD3 Complex - metabolism CD69 antigen Cell culture Cell proliferation Cytolytic activity Cytotoxicity Effector cells ErbB-2 protein Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - immunology Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - immunology Growth factors Humans Immunology Immunotherapy Interferon K562 Cells Kinases Laboratories Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Melanoma Melanoma - drug therapy Melanoma - immunology Melanoma - pathology Metastasis Mice Mice, SCID Monoclonal antibodies Receptor, ErbB-2 - genetics Receptor, ErbB-2 - immunology Receptor, ErbB-2 - metabolism Surgery T-Lymphocytes - immunology T-Lymphocytes - pathology Therapy Thoracic surgery Toxicity Tumor cells Tumors Xenograft Model Antitumor Assays Xenografts γ-Interferon
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