Background factors of reflux esophagitis and non-erosive reflux disease: a cross-sectional study of 10,837 subjects in Japan
Despite the high prevalence of gastroesophageal reflux disease (GERD), its risk factors are still a subject of controversy. This is probably due to inadequate distinction between reflux esophagitis (RE) and non-erosive reflux disease (NERD), and is also due to inadequate evaluation of adjacent stoma...
Gespeichert in:
| Veröffentlicht in: | PloS one 2013-07, Vol.8 (7), p.e69891-e69891 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e69891 |
|---|---|
| container_issue | 7 |
| container_start_page | e69891 |
| container_title | PloS one |
| container_volume | 8 |
| creator | Minatsuki, Chihiro Yamamichi, Nobutake Shimamoto, Takeshi Kakimoto, Hikaru Takahashi, Yu Fujishiro, Mitsuhiro Sakaguchi, Yoshiki Nakayama, Chiemi Konno-Shimizu, Maki Matsuda, Rie Mochizuki, Satoshi Asada-Hirayama, Itsuko Tsuji, Yosuke Kodashima, Shinya Ono, Satoshi Niimi, Keiko Mitsushima, Toru Koike, Kazuhiko |
| description | Despite the high prevalence of gastroesophageal reflux disease (GERD), its risk factors are still a subject of controversy. This is probably due to inadequate distinction between reflux esophagitis (RE) and non-erosive reflux disease (NERD), and is also due to inadequate evaluation of adjacent stomach. Our aim is therefore to define background factors of RE and NERD independently, based on the evaluation of Helicobacter pylori infection and gastric atrophy.
We analyzed 10,837 healthy Japanese subjects (6,332 men and 4,505 women, aged 20-87 years) who underwent upper gastrointestinal endoscopy. RE was diagnosed as the presence of mucosal break, and NERD was diagnosed as the presence of heartburn and/or acid regurgitation in RE-free subjects. Using GERD-free subjects as control, background factors for RE and NERD were separately analyzed using logistic regression to evaluate standardized coefficients (SC), odds ratio (OR), and p-value.
Of the 10,837 study subjects, we diagnosed 733 (6.8%) as RE and 1,722 (15.9%) as NERD. For RE, male gender (SC = 0.557, OR = 1.75), HP non-infection (SC = 0.552, OR = 1.74), higher pepsinogen I/II ratio (SC = 0.496, OR = 1.64), higher BMI (SC = 0.464, OR = 1.60), alcohol drinking (SC = 0.161, OR = 1.17), older age (SC = 0.148, OR = 1.16), and smoking (SC = 0.129, OR = 1.14) are positively correlated factors. For NERD, HP infection (SC = 0.106, OR = 1.11), female gender (SC = 0.099, OR = 1.10), younger age (SC = 0.099, OR = 1.10), higher pepsinogen I/II ratio (SC = 0.099, OR = 1.10), smoking (SC = 0.080, OR = 1.08), higher BMI (SC = 0.078, OR = 1.08), and alcohol drinking (SC = 0.076, OR = 1.08) are positively correlated factors. Prevalence of RE in subjects with chronic HP infection and successful HP eradication denotes significant difference (2.3% and 8.8%; p |
| doi_str_mv | 10.1371/journal.pone.0069891 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_1428143691</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_ea8b9bb829f5448e8bb1c08c1289a54b</doaj_id><sourcerecordid>1418644888</sourcerecordid><originalsourceid>FETCH-LOGICAL-c592t-40a79d6d4e0293d4841651f2d237d2c1f0925575d9299c20f99e5864e797a2743</originalsourceid><addsrcrecordid>eNptkk1v1DAQhiMEoqXwDxBY4sKBLP5KbHNAgoqPokpc4GxNbGfrJWtv7aSiEj8ep5utWsTJlueZd2Y8b1U9J3hFmCBvN3FKAYbVLga3wrhVUpEH1TFRjNYtxezhnftR9STnDcYNk237uDqiTFEqOT-u_nwE82ud4hQs6sGMMWUUe5RcP0y_kctxdwFrP_qMoBAhhtqlmP2VOyDWZwfZvUOATInkOjsz-lg6Q3mc7PWsRvAbyQTKU7cpwYx8QN9gB-Fp9aiHIbtny3lS_fz86cfp1_r8-5ez0w_ntWkUHWuOQSjbWu4wVcxyyUnbkJ5ayoSlhvRY0aYRjVVUKUNxr5RrZMudUAKo4OykernX3Q0x6-XjsiacSsJZq0ghzvaEjbDRu-S3kK51BK9vHmJaa0ijN4PTDmSnuk5S1TecSye7jhgsDaFSQcO7ovV-qTZ1W2eNC2OC4Z7o_UjwF3odrzQTlAsmi8DrRSDFy8nlUW99Nm4YILg4zX2TMh2XckZf_YP-fzq-p242VBZ32wzBejbTIUvPZtKLmUrai7uD3CYd3MP-AkK7x8E</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1428143691</pqid></control><display><type>article</type><title>Background factors of reflux esophagitis and non-erosive reflux disease: a cross-sectional study of 10,837 subjects in Japan</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Minatsuki, Chihiro ; Yamamichi, Nobutake ; Shimamoto, Takeshi ; Kakimoto, Hikaru ; Takahashi, Yu ; Fujishiro, Mitsuhiro ; Sakaguchi, Yoshiki ; Nakayama, Chiemi ; Konno-Shimizu, Maki ; Matsuda, Rie ; Mochizuki, Satoshi ; Asada-Hirayama, Itsuko ; Tsuji, Yosuke ; Kodashima, Shinya ; Ono, Satoshi ; Niimi, Keiko ; Mitsushima, Toru ; Koike, Kazuhiko</creator><contributor>Katoh, Masaru</contributor><creatorcontrib>Minatsuki, Chihiro ; Yamamichi, Nobutake ; Shimamoto, Takeshi ; Kakimoto, Hikaru ; Takahashi, Yu ; Fujishiro, Mitsuhiro ; Sakaguchi, Yoshiki ; Nakayama, Chiemi ; Konno-Shimizu, Maki ; Matsuda, Rie ; Mochizuki, Satoshi ; Asada-Hirayama, Itsuko ; Tsuji, Yosuke ; Kodashima, Shinya ; Ono, Satoshi ; Niimi, Keiko ; Mitsushima, Toru ; Koike, Kazuhiko ; Katoh, Masaru</creatorcontrib><description>Despite the high prevalence of gastroesophageal reflux disease (GERD), its risk factors are still a subject of controversy. This is probably due to inadequate distinction between reflux esophagitis (RE) and non-erosive reflux disease (NERD), and is also due to inadequate evaluation of adjacent stomach. Our aim is therefore to define background factors of RE and NERD independently, based on the evaluation of Helicobacter pylori infection and gastric atrophy.
We analyzed 10,837 healthy Japanese subjects (6,332 men and 4,505 women, aged 20-87 years) who underwent upper gastrointestinal endoscopy. RE was diagnosed as the presence of mucosal break, and NERD was diagnosed as the presence of heartburn and/or acid regurgitation in RE-free subjects. Using GERD-free subjects as control, background factors for RE and NERD were separately analyzed using logistic regression to evaluate standardized coefficients (SC), odds ratio (OR), and p-value.
Of the 10,837 study subjects, we diagnosed 733 (6.8%) as RE and 1,722 (15.9%) as NERD. For RE, male gender (SC = 0.557, OR = 1.75), HP non-infection (SC = 0.552, OR = 1.74), higher pepsinogen I/II ratio (SC = 0.496, OR = 1.64), higher BMI (SC = 0.464, OR = 1.60), alcohol drinking (SC = 0.161, OR = 1.17), older age (SC = 0.148, OR = 1.16), and smoking (SC = 0.129, OR = 1.14) are positively correlated factors. For NERD, HP infection (SC = 0.106, OR = 1.11), female gender (SC = 0.099, OR = 1.10), younger age (SC = 0.099, OR = 1.10), higher pepsinogen I/II ratio (SC = 0.099, OR = 1.10), smoking (SC = 0.080, OR = 1.08), higher BMI (SC = 0.078, OR = 1.08), and alcohol drinking (SC = 0.076, OR = 1.08) are positively correlated factors. Prevalence of RE in subjects with chronic HP infection and successful HP eradication denotes significant difference (2.3% and 8.8%; p<0.0001), whereas that of NERD shows no difference (18.2% and 20.8%; p = 0.064).
Significantly associated factors of NERD are considerably different from those of RE, indicating that these two disorders are pathophysiologically distinct. Eradication of Helicobacter pylori may have disadvantageous effects on RE but not on NERD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0069891</identifier><identifier>PMID: 23922844</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Alcohol use ; Alcoholic beverages ; Atrophy ; Body mass ; Chronic infection ; Cross-Sectional Studies ; Drinking behavior ; Endoscopy ; Esophagitis ; Esophagitis, Peptic - complications ; Esophagitis, Peptic - epidemiology ; Esophagitis, Peptic - microbiology ; Evaluation ; Female ; Gastroenterology ; Gastroesophageal reflux ; Gastroesophageal Reflux - complications ; Gastroesophageal Reflux - epidemiology ; Gastroesophageal Reflux - microbiology ; Health risks ; Helicobacter Infections - complications ; Helicobacter Infections - prevention & control ; Helicobacter pylori ; Helicobacter pylori - physiology ; Humans ; Infections ; Japan - epidemiology ; Male ; Mathematics ; Medicine ; Middle Aged ; Mucosa ; Multivariate analysis ; Population ; Prevalence ; Regression analysis ; Regurgitation ; Risk analysis ; Risk Factors ; Smoking ; Stomach</subject><ispartof>PloS one, 2013-07, Vol.8 (7), p.e69891-e69891</ispartof><rights>2013 Minatsuki et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Minatsuki et al 2013 Minatsuki et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c592t-40a79d6d4e0293d4841651f2d237d2c1f0925575d9299c20f99e5864e797a2743</citedby><cites>FETCH-LOGICAL-c592t-40a79d6d4e0293d4841651f2d237d2c1f0925575d9299c20f99e5864e797a2743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724738/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724738/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23922844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Katoh, Masaru</contributor><creatorcontrib>Minatsuki, Chihiro</creatorcontrib><creatorcontrib>Yamamichi, Nobutake</creatorcontrib><creatorcontrib>Shimamoto, Takeshi</creatorcontrib><creatorcontrib>Kakimoto, Hikaru</creatorcontrib><creatorcontrib>Takahashi, Yu</creatorcontrib><creatorcontrib>Fujishiro, Mitsuhiro</creatorcontrib><creatorcontrib>Sakaguchi, Yoshiki</creatorcontrib><creatorcontrib>Nakayama, Chiemi</creatorcontrib><creatorcontrib>Konno-Shimizu, Maki</creatorcontrib><creatorcontrib>Matsuda, Rie</creatorcontrib><creatorcontrib>Mochizuki, Satoshi</creatorcontrib><creatorcontrib>Asada-Hirayama, Itsuko</creatorcontrib><creatorcontrib>Tsuji, Yosuke</creatorcontrib><creatorcontrib>Kodashima, Shinya</creatorcontrib><creatorcontrib>Ono, Satoshi</creatorcontrib><creatorcontrib>Niimi, Keiko</creatorcontrib><creatorcontrib>Mitsushima, Toru</creatorcontrib><creatorcontrib>Koike, Kazuhiko</creatorcontrib><title>Background factors of reflux esophagitis and non-erosive reflux disease: a cross-sectional study of 10,837 subjects in Japan</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Despite the high prevalence of gastroesophageal reflux disease (GERD), its risk factors are still a subject of controversy. This is probably due to inadequate distinction between reflux esophagitis (RE) and non-erosive reflux disease (NERD), and is also due to inadequate evaluation of adjacent stomach. Our aim is therefore to define background factors of RE and NERD independently, based on the evaluation of Helicobacter pylori infection and gastric atrophy.
We analyzed 10,837 healthy Japanese subjects (6,332 men and 4,505 women, aged 20-87 years) who underwent upper gastrointestinal endoscopy. RE was diagnosed as the presence of mucosal break, and NERD was diagnosed as the presence of heartburn and/or acid regurgitation in RE-free subjects. Using GERD-free subjects as control, background factors for RE and NERD were separately analyzed using logistic regression to evaluate standardized coefficients (SC), odds ratio (OR), and p-value.
Of the 10,837 study subjects, we diagnosed 733 (6.8%) as RE and 1,722 (15.9%) as NERD. For RE, male gender (SC = 0.557, OR = 1.75), HP non-infection (SC = 0.552, OR = 1.74), higher pepsinogen I/II ratio (SC = 0.496, OR = 1.64), higher BMI (SC = 0.464, OR = 1.60), alcohol drinking (SC = 0.161, OR = 1.17), older age (SC = 0.148, OR = 1.16), and smoking (SC = 0.129, OR = 1.14) are positively correlated factors. For NERD, HP infection (SC = 0.106, OR = 1.11), female gender (SC = 0.099, OR = 1.10), younger age (SC = 0.099, OR = 1.10), higher pepsinogen I/II ratio (SC = 0.099, OR = 1.10), smoking (SC = 0.080, OR = 1.08), higher BMI (SC = 0.078, OR = 1.08), and alcohol drinking (SC = 0.076, OR = 1.08) are positively correlated factors. Prevalence of RE in subjects with chronic HP infection and successful HP eradication denotes significant difference (2.3% and 8.8%; p<0.0001), whereas that of NERD shows no difference (18.2% and 20.8%; p = 0.064).
Significantly associated factors of NERD are considerably different from those of RE, indicating that these two disorders are pathophysiologically distinct. Eradication of Helicobacter pylori may have disadvantageous effects on RE but not on NERD.</description><subject>Adult</subject><subject>Aged</subject><subject>Alcohol use</subject><subject>Alcoholic beverages</subject><subject>Atrophy</subject><subject>Body mass</subject><subject>Chronic infection</subject><subject>Cross-Sectional Studies</subject><subject>Drinking behavior</subject><subject>Endoscopy</subject><subject>Esophagitis</subject><subject>Esophagitis, Peptic - complications</subject><subject>Esophagitis, Peptic - epidemiology</subject><subject>Esophagitis, Peptic - microbiology</subject><subject>Evaluation</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gastroesophageal reflux</subject><subject>Gastroesophageal Reflux - complications</subject><subject>Gastroesophageal Reflux - epidemiology</subject><subject>Gastroesophageal Reflux - microbiology</subject><subject>Health risks</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter Infections - prevention & control</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - physiology</subject><subject>Humans</subject><subject>Infections</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Mathematics</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Mucosa</subject><subject>Multivariate analysis</subject><subject>Population</subject><subject>Prevalence</subject><subject>Regression analysis</subject><subject>Regurgitation</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Smoking</subject><subject>Stomach</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1v1DAQhiMEoqXwDxBY4sKBLP5KbHNAgoqPokpc4GxNbGfrJWtv7aSiEj8ep5utWsTJlueZd2Y8b1U9J3hFmCBvN3FKAYbVLga3wrhVUpEH1TFRjNYtxezhnftR9STnDcYNk237uDqiTFEqOT-u_nwE82ud4hQs6sGMMWUUe5RcP0y_kctxdwFrP_qMoBAhhtqlmP2VOyDWZwfZvUOATInkOjsz-lg6Q3mc7PWsRvAbyQTKU7cpwYx8QN9gB-Fp9aiHIbtny3lS_fz86cfp1_r8-5ez0w_ntWkUHWuOQSjbWu4wVcxyyUnbkJ5ayoSlhvRY0aYRjVVUKUNxr5RrZMudUAKo4OykernX3Q0x6-XjsiacSsJZq0ghzvaEjbDRu-S3kK51BK9vHmJaa0ijN4PTDmSnuk5S1TecSye7jhgsDaFSQcO7ovV-qTZ1W2eNC2OC4Z7o_UjwF3odrzQTlAsmi8DrRSDFy8nlUW99Nm4YILg4zX2TMh2XckZf_YP-fzq-p242VBZ32wzBejbTIUvPZtKLmUrai7uD3CYd3MP-AkK7x8E</recordid><startdate>20130726</startdate><enddate>20130726</enddate><creator>Minatsuki, Chihiro</creator><creator>Yamamichi, Nobutake</creator><creator>Shimamoto, Takeshi</creator><creator>Kakimoto, Hikaru</creator><creator>Takahashi, Yu</creator><creator>Fujishiro, Mitsuhiro</creator><creator>Sakaguchi, Yoshiki</creator><creator>Nakayama, Chiemi</creator><creator>Konno-Shimizu, Maki</creator><creator>Matsuda, Rie</creator><creator>Mochizuki, Satoshi</creator><creator>Asada-Hirayama, Itsuko</creator><creator>Tsuji, Yosuke</creator><creator>Kodashima, Shinya</creator><creator>Ono, Satoshi</creator><creator>Niimi, Keiko</creator><creator>Mitsushima, Toru</creator><creator>Koike, Kazuhiko</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130726</creationdate><title>Background factors of reflux esophagitis and non-erosive reflux disease: a cross-sectional study of 10,837 subjects in Japan</title><author>Minatsuki, Chihiro ; Yamamichi, Nobutake ; Shimamoto, Takeshi ; Kakimoto, Hikaru ; Takahashi, Yu ; Fujishiro, Mitsuhiro ; Sakaguchi, Yoshiki ; Nakayama, Chiemi ; Konno-Shimizu, Maki ; Matsuda, Rie ; Mochizuki, Satoshi ; Asada-Hirayama, Itsuko ; Tsuji, Yosuke ; Kodashima, Shinya ; Ono, Satoshi ; Niimi, Keiko ; Mitsushima, Toru ; Koike, Kazuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c592t-40a79d6d4e0293d4841651f2d237d2c1f0925575d9299c20f99e5864e797a2743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alcohol use</topic><topic>Alcoholic beverages</topic><topic>Atrophy</topic><topic>Body mass</topic><topic>Chronic infection</topic><topic>Cross-Sectional Studies</topic><topic>Drinking behavior</topic><topic>Endoscopy</topic><topic>Esophagitis</topic><topic>Esophagitis, Peptic - complications</topic><topic>Esophagitis, Peptic - epidemiology</topic><topic>Esophagitis, Peptic - microbiology</topic><topic>Evaluation</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Gastroesophageal reflux</topic><topic>Gastroesophageal Reflux - complications</topic><topic>Gastroesophageal Reflux - epidemiology</topic><topic>Gastroesophageal Reflux - microbiology</topic><topic>Health risks</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter Infections - prevention & control</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - physiology</topic><topic>Humans</topic><topic>Infections</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Mathematics</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Mucosa</topic><topic>Multivariate analysis</topic><topic>Population</topic><topic>Prevalence</topic><topic>Regression analysis</topic><topic>Regurgitation</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Smoking</topic><topic>Stomach</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Minatsuki, Chihiro</creatorcontrib><creatorcontrib>Yamamichi, Nobutake</creatorcontrib><creatorcontrib>Shimamoto, Takeshi</creatorcontrib><creatorcontrib>Kakimoto, Hikaru</creatorcontrib><creatorcontrib>Takahashi, Yu</creatorcontrib><creatorcontrib>Fujishiro, Mitsuhiro</creatorcontrib><creatorcontrib>Sakaguchi, Yoshiki</creatorcontrib><creatorcontrib>Nakayama, Chiemi</creatorcontrib><creatorcontrib>Konno-Shimizu, Maki</creatorcontrib><creatorcontrib>Matsuda, Rie</creatorcontrib><creatorcontrib>Mochizuki, Satoshi</creatorcontrib><creatorcontrib>Asada-Hirayama, Itsuko</creatorcontrib><creatorcontrib>Tsuji, Yosuke</creatorcontrib><creatorcontrib>Kodashima, Shinya</creatorcontrib><creatorcontrib>Ono, Satoshi</creatorcontrib><creatorcontrib>Niimi, Keiko</creatorcontrib><creatorcontrib>Mitsushima, Toru</creatorcontrib><creatorcontrib>Koike, Kazuhiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Minatsuki, Chihiro</au><au>Yamamichi, Nobutake</au><au>Shimamoto, Takeshi</au><au>Kakimoto, Hikaru</au><au>Takahashi, Yu</au><au>Fujishiro, Mitsuhiro</au><au>Sakaguchi, Yoshiki</au><au>Nakayama, Chiemi</au><au>Konno-Shimizu, Maki</au><au>Matsuda, Rie</au><au>Mochizuki, Satoshi</au><au>Asada-Hirayama, Itsuko</au><au>Tsuji, Yosuke</au><au>Kodashima, Shinya</au><au>Ono, Satoshi</au><au>Niimi, Keiko</au><au>Mitsushima, Toru</au><au>Koike, Kazuhiko</au><au>Katoh, Masaru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Background factors of reflux esophagitis and non-erosive reflux disease: a cross-sectional study of 10,837 subjects in Japan</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-07-26</date><risdate>2013</risdate><volume>8</volume><issue>7</issue><spage>e69891</spage><epage>e69891</epage><pages>e69891-e69891</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Despite the high prevalence of gastroesophageal reflux disease (GERD), its risk factors are still a subject of controversy. This is probably due to inadequate distinction between reflux esophagitis (RE) and non-erosive reflux disease (NERD), and is also due to inadequate evaluation of adjacent stomach. Our aim is therefore to define background factors of RE and NERD independently, based on the evaluation of Helicobacter pylori infection and gastric atrophy.
We analyzed 10,837 healthy Japanese subjects (6,332 men and 4,505 women, aged 20-87 years) who underwent upper gastrointestinal endoscopy. RE was diagnosed as the presence of mucosal break, and NERD was diagnosed as the presence of heartburn and/or acid regurgitation in RE-free subjects. Using GERD-free subjects as control, background factors for RE and NERD were separately analyzed using logistic regression to evaluate standardized coefficients (SC), odds ratio (OR), and p-value.
Of the 10,837 study subjects, we diagnosed 733 (6.8%) as RE and 1,722 (15.9%) as NERD. For RE, male gender (SC = 0.557, OR = 1.75), HP non-infection (SC = 0.552, OR = 1.74), higher pepsinogen I/II ratio (SC = 0.496, OR = 1.64), higher BMI (SC = 0.464, OR = 1.60), alcohol drinking (SC = 0.161, OR = 1.17), older age (SC = 0.148, OR = 1.16), and smoking (SC = 0.129, OR = 1.14) are positively correlated factors. For NERD, HP infection (SC = 0.106, OR = 1.11), female gender (SC = 0.099, OR = 1.10), younger age (SC = 0.099, OR = 1.10), higher pepsinogen I/II ratio (SC = 0.099, OR = 1.10), smoking (SC = 0.080, OR = 1.08), higher BMI (SC = 0.078, OR = 1.08), and alcohol drinking (SC = 0.076, OR = 1.08) are positively correlated factors. Prevalence of RE in subjects with chronic HP infection and successful HP eradication denotes significant difference (2.3% and 8.8%; p<0.0001), whereas that of NERD shows no difference (18.2% and 20.8%; p = 0.064).
Significantly associated factors of NERD are considerably different from those of RE, indicating that these two disorders are pathophysiologically distinct. Eradication of Helicobacter pylori may have disadvantageous effects on RE but not on NERD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23922844</pmid><doi>10.1371/journal.pone.0069891</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-07, Vol.8 (7), p.e69891-e69891 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1428143691 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Aged Alcohol use Alcoholic beverages Atrophy Body mass Chronic infection Cross-Sectional Studies Drinking behavior Endoscopy Esophagitis Esophagitis, Peptic - complications Esophagitis, Peptic - epidemiology Esophagitis, Peptic - microbiology Evaluation Female Gastroenterology Gastroesophageal reflux Gastroesophageal Reflux - complications Gastroesophageal Reflux - epidemiology Gastroesophageal Reflux - microbiology Health risks Helicobacter Infections - complications Helicobacter Infections - prevention & control Helicobacter pylori Helicobacter pylori - physiology Humans Infections Japan - epidemiology Male Mathematics Medicine Middle Aged Mucosa Multivariate analysis Population Prevalence Regression analysis Regurgitation Risk analysis Risk Factors Smoking Stomach |
| title | Background factors of reflux esophagitis and non-erosive reflux disease: a cross-sectional study of 10,837 subjects in Japan |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T06%3A10%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Background%20factors%20of%20reflux%20esophagitis%20and%20non-erosive%20reflux%20disease:%20a%20cross-sectional%20study%20of%2010,837%20subjects%20in%20Japan&rft.jtitle=PloS%20one&rft.au=Minatsuki,%20Chihiro&rft.date=2013-07-26&rft.volume=8&rft.issue=7&rft.spage=e69891&rft.epage=e69891&rft.pages=e69891-e69891&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0069891&rft_dat=%3Cproquest_plos_%3E1418644888%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1428143691&rft_id=info:pmid/23922844&rft_doaj_id=oai_doaj_org_article_ea8b9bb829f5448e8bb1c08c1289a54b&rfr_iscdi=true |