Transcriptomic analysis of insulin-sensitive tissues from anti-diabetic drug treated ZDF rats, a T2DM animal model

Gene expression changes have been associated with type 2 diabetes mellitus (T2DM); however, the alterations are not fully understood. We investigated the effects of anti-diabetic drugs on gene expression in Zucker diabetic fatty (ZDF) rats using oligonucleotide microarray technology to identify gene...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e69624
Hauptverfasser:	Kim, Yo Na, Kim, Sangok, Kim, Il-Yong, Shin, Jae Hoon, Cho, Sooyoung, Yi, Sun Shin, Kim, Wan Kyu, Kim, Kyung-Sub, Lee, Sanghyuk, Seong, Je Kyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Animal tissues Animals Antidiabetics Autoimmune diseases Biological activity Biological effects Biology Cluster Analysis Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - genetics Disease Models, Animal DNA microarrays Drugs Gene expression Gene Expression Profiling Gene Regulatory Networks - drug effects Genes Genomics Glucose Tolerance Test Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Insulin Insulin - pharmacology Insulin resistance Kinases Liver Lupus Male Medicine Muscles Oligonucleotides Organ Specificity - drug effects Organ Specificity - genetics Oxidative phosphorylation Oxidative Phosphorylation - drug effects Pancreas Pathogenesis Phosphorylation Rats Rats, Zucker Real-Time Polymerase Chain Reaction Reproducibility of Results Rodents Rosiglitazone Signal transduction Signaling Skeletal muscle Systemic lupus erythematosus Transcription, Genetic - drug effects Veterinary colleges
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