Telomere length and physical performance at older ages: an individual participant meta-analysis
Telomeres are involved in cellular ageing and shorten with increasing age. If telomere length is a valuable biomarker of ageing, then telomere shortening should be associated with worse physical performance, an ageing trait, but evidence for such an association is lacking. The purpose of this study...
Gespeichert in:
Veröffentlicht in: | PloS one 2013-07, Vol.8 (7), p.e69526-e69526 |
---|---|
Hauptverfasser: | , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | e69526 |
---|---|
container_issue | 7 |
container_start_page | e69526 |
container_title | PloS one |
container_volume | 8 |
creator | Gardner, Michael P Martin-Ruiz, Carmen Cooper, Rachel Hardy, Rebecca Sayer, Avan Aihie Cooper, Cyrus Deary, Ian J Gallacher, John Harris, Sarah E Shiels, Paul G Starr, John M Kuh, Diana von Zglinicki, Thomas Ben-Shlomo, Yoav |
description | Telomeres are involved in cellular ageing and shorten with increasing age. If telomere length is a valuable biomarker of ageing, then telomere shortening should be associated with worse physical performance, an ageing trait, but evidence for such an association is lacking. The purpose of this study was to examine whether change in telomere length is associated with physical performance.
Using data from four UK adult cohorts (ages 53-80 years at baseline), we undertook cross-sectional and longitudinal analyses. We analysed each study separately and then used meta-analytic methods to pool the results. Physical performance was measured using walking and chair rise speed, standing balance time and grip strength. Telomere length was measured by quantitative real-time polymerase chain reaction (PCR) in whole blood at baseline and follow-up (time 1, time 2).
Total sample sizes in meta-analyses ranged from 1,217 to 3,707. There was little evidence that telomere length was associated with walking speed, balance or grip strength, though weak associations were seen with chair rise speed and grip strength at baseline (p = 0.02 and 0.01 respectively). Faster chair rise speed at follow-up, was associated with a smaller decline in telomere length between time 1 and time 2 (standardised coefficient per SD increase 0.061, 95% CI 0.006, 0.115, p = 0.03) but this was consistent with chance (p =0.08) after further adjustment.
Whereas shortening of leukocyte telomeres might be an important measure of cellular ageing, there is little evidence that it is a strong biomarker for physical performance. |
doi_str_mv | 10.1371/journal.pone.0069526 |
format | Article |
fullrecord | <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_1428143585</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_400c9f8410bd4f88ab1f8dbf9beeca1a</doaj_id><sourcerecordid>3054537511</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-f14ef0ce9195c9ce21f820b3474512047b17864c55ad48b82721027a9ad0fec73</originalsourceid><addsrcrecordid>eNptUk1v1DAUjBCIloV_gCASFy67-CuJzQEJVXxUqsSlnK0X-3k3KycOdlKp_x6nm1Yt4mTLnpk3Y09RvKVkR3lDPx3DHAfwuzEMuCOkVhWrnxXnVHG2rRnhzx_tz4pXKR0Jqbis65fFGeOKsYbT80Jfow89Riw9DvvpUMJgy_FwmzoDvhwxuhB7GAyWMJXBW4wl7DF9zriyG2x309l5AUKcOtONMExljxNsIVvLIul18cKBT_hmXTfF7-_fri9-bq9-_bi8-Hq1Ndn2tHVUoCMGFVWVUQYZdZKRlotGVJQR0bS0kbUwVQVWyFayhlHCGlBgiUPT8E3x_qQ7-pD0-jZJU8EkFbySVUZcnhA2wFGPsesh3uoAnb47CHGv70J41IIQo5wUlLRWOCmhzXZs61SLaIBC1vqyTpvbHq3BYYrgn4g-vRm6g96HG80bJhRdzHxcBWL4M2OadN8lg97DgGFefNMctyL5BzfFh3-g_08nTigTQ0oR3YMZSvTSl3uWXvqi175k2rvHQR5I9wXhfwG-2b-i</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1428143585</pqid></control><display><type>article</type><title>Telomere length and physical performance at older ages: an individual participant meta-analysis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Gardner, Michael P ; Martin-Ruiz, Carmen ; Cooper, Rachel ; Hardy, Rebecca ; Sayer, Avan Aihie ; Cooper, Cyrus ; Deary, Ian J ; Gallacher, John ; Harris, Sarah E ; Shiels, Paul G ; Starr, John M ; Kuh, Diana ; von Zglinicki, Thomas ; Ben-Shlomo, Yoav</creator><contributor>Vina, Jose</contributor><creatorcontrib>Gardner, Michael P ; Martin-Ruiz, Carmen ; Cooper, Rachel ; Hardy, Rebecca ; Sayer, Avan Aihie ; Cooper, Cyrus ; Deary, Ian J ; Gallacher, John ; Harris, Sarah E ; Shiels, Paul G ; Starr, John M ; Kuh, Diana ; von Zglinicki, Thomas ; Ben-Shlomo, Yoav ; Halcyon study team ; the Halcyon study team ; Vina, Jose</creatorcontrib><description>Telomeres are involved in cellular ageing and shorten with increasing age. If telomere length is a valuable biomarker of ageing, then telomere shortening should be associated with worse physical performance, an ageing trait, but evidence for such an association is lacking. The purpose of this study was to examine whether change in telomere length is associated with physical performance.
Using data from four UK adult cohorts (ages 53-80 years at baseline), we undertook cross-sectional and longitudinal analyses. We analysed each study separately and then used meta-analytic methods to pool the results. Physical performance was measured using walking and chair rise speed, standing balance time and grip strength. Telomere length was measured by quantitative real-time polymerase chain reaction (PCR) in whole blood at baseline and follow-up (time 1, time 2).
Total sample sizes in meta-analyses ranged from 1,217 to 3,707. There was little evidence that telomere length was associated with walking speed, balance or grip strength, though weak associations were seen with chair rise speed and grip strength at baseline (p = 0.02 and 0.01 respectively). Faster chair rise speed at follow-up, was associated with a smaller decline in telomere length between time 1 and time 2 (standardised coefficient per SD increase 0.061, 95% CI 0.006, 0.115, p = 0.03) but this was consistent with chance (p =0.08) after further adjustment.
Whereas shortening of leukocyte telomeres might be an important measure of cellular ageing, there is little evidence that it is a strong biomarker for physical performance.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0069526</identifier><identifier>PMID: 23922731</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Balance ; Bioindicators ; Biology ; Biomarkers ; Chromosomes ; Ethics ; Female ; Grip strength ; Halcyon ; Hand Strength - physiology ; Humans ; Leukocytes ; Male ; Mathematics ; Medicine ; Meta-analysis ; Middle Aged ; Physical Fitness - physiology ; Polymerase chain reaction ; Posture - physiology ; Socioeconomic factors ; Studies ; Telomere Homeostasis - physiology ; Telomeres ; Walking ; Walking - physiology ; Yeast</subject><ispartof>PloS one, 2013-07, Vol.8 (7), p.e69526-e69526</ispartof><rights>2013 Gardner et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Gardner et al 2013 Gardner et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-f14ef0ce9195c9ce21f820b3474512047b17864c55ad48b82721027a9ad0fec73</citedby><cites>FETCH-LOGICAL-c526t-f14ef0ce9195c9ce21f820b3474512047b17864c55ad48b82721027a9ad0fec73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724915/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724915/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23922731$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Vina, Jose</contributor><creatorcontrib>Gardner, Michael P</creatorcontrib><creatorcontrib>Martin-Ruiz, Carmen</creatorcontrib><creatorcontrib>Cooper, Rachel</creatorcontrib><creatorcontrib>Hardy, Rebecca</creatorcontrib><creatorcontrib>Sayer, Avan Aihie</creatorcontrib><creatorcontrib>Cooper, Cyrus</creatorcontrib><creatorcontrib>Deary, Ian J</creatorcontrib><creatorcontrib>Gallacher, John</creatorcontrib><creatorcontrib>Harris, Sarah E</creatorcontrib><creatorcontrib>Shiels, Paul G</creatorcontrib><creatorcontrib>Starr, John M</creatorcontrib><creatorcontrib>Kuh, Diana</creatorcontrib><creatorcontrib>von Zglinicki, Thomas</creatorcontrib><creatorcontrib>Ben-Shlomo, Yoav</creatorcontrib><creatorcontrib>Halcyon study team</creatorcontrib><creatorcontrib>the Halcyon study team</creatorcontrib><title>Telomere length and physical performance at older ages: an individual participant meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Telomeres are involved in cellular ageing and shorten with increasing age. If telomere length is a valuable biomarker of ageing, then telomere shortening should be associated with worse physical performance, an ageing trait, but evidence for such an association is lacking. The purpose of this study was to examine whether change in telomere length is associated with physical performance.
Using data from four UK adult cohorts (ages 53-80 years at baseline), we undertook cross-sectional and longitudinal analyses. We analysed each study separately and then used meta-analytic methods to pool the results. Physical performance was measured using walking and chair rise speed, standing balance time and grip strength. Telomere length was measured by quantitative real-time polymerase chain reaction (PCR) in whole blood at baseline and follow-up (time 1, time 2).
Total sample sizes in meta-analyses ranged from 1,217 to 3,707. There was little evidence that telomere length was associated with walking speed, balance or grip strength, though weak associations were seen with chair rise speed and grip strength at baseline (p = 0.02 and 0.01 respectively). Faster chair rise speed at follow-up, was associated with a smaller decline in telomere length between time 1 and time 2 (standardised coefficient per SD increase 0.061, 95% CI 0.006, 0.115, p = 0.03) but this was consistent with chance (p =0.08) after further adjustment.
Whereas shortening of leukocyte telomeres might be an important measure of cellular ageing, there is little evidence that it is a strong biomarker for physical performance.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Balance</subject><subject>Bioindicators</subject><subject>Biology</subject><subject>Biomarkers</subject><subject>Chromosomes</subject><subject>Ethics</subject><subject>Female</subject><subject>Grip strength</subject><subject>Halcyon</subject><subject>Hand Strength - physiology</subject><subject>Humans</subject><subject>Leukocytes</subject><subject>Male</subject><subject>Mathematics</subject><subject>Medicine</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Physical Fitness - physiology</subject><subject>Polymerase chain reaction</subject><subject>Posture - physiology</subject><subject>Socioeconomic factors</subject><subject>Studies</subject><subject>Telomere Homeostasis - physiology</subject><subject>Telomeres</subject><subject>Walking</subject><subject>Walking - physiology</subject><subject>Yeast</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1v1DAUjBCIloV_gCASFy67-CuJzQEJVXxUqsSlnK0X-3k3KycOdlKp_x6nm1Yt4mTLnpk3Y09RvKVkR3lDPx3DHAfwuzEMuCOkVhWrnxXnVHG2rRnhzx_tz4pXKR0Jqbis65fFGeOKsYbT80Jfow89Riw9DvvpUMJgy_FwmzoDvhwxuhB7GAyWMJXBW4wl7DF9zriyG2x309l5AUKcOtONMExljxNsIVvLIul18cKBT_hmXTfF7-_fri9-bq9-_bi8-Hq1Ndn2tHVUoCMGFVWVUQYZdZKRlotGVJQR0bS0kbUwVQVWyFayhlHCGlBgiUPT8E3x_qQ7-pD0-jZJU8EkFbySVUZcnhA2wFGPsesh3uoAnb47CHGv70J41IIQo5wUlLRWOCmhzXZs61SLaIBC1vqyTpvbHq3BYYrgn4g-vRm6g96HG80bJhRdzHxcBWL4M2OadN8lg97DgGFefNMctyL5BzfFh3-g_08nTigTQ0oR3YMZSvTSl3uWXvqi175k2rvHQR5I9wXhfwG-2b-i</recordid><startdate>20130726</startdate><enddate>20130726</enddate><creator>Gardner, Michael P</creator><creator>Martin-Ruiz, Carmen</creator><creator>Cooper, Rachel</creator><creator>Hardy, Rebecca</creator><creator>Sayer, Avan Aihie</creator><creator>Cooper, Cyrus</creator><creator>Deary, Ian J</creator><creator>Gallacher, John</creator><creator>Harris, Sarah E</creator><creator>Shiels, Paul G</creator><creator>Starr, John M</creator><creator>Kuh, Diana</creator><creator>von Zglinicki, Thomas</creator><creator>Ben-Shlomo, Yoav</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130726</creationdate><title>Telomere length and physical performance at older ages: an individual participant meta-analysis</title><author>Gardner, Michael P ; Martin-Ruiz, Carmen ; Cooper, Rachel ; Hardy, Rebecca ; Sayer, Avan Aihie ; Cooper, Cyrus ; Deary, Ian J ; Gallacher, John ; Harris, Sarah E ; Shiels, Paul G ; Starr, John M ; Kuh, Diana ; von Zglinicki, Thomas ; Ben-Shlomo, Yoav</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-f14ef0ce9195c9ce21f820b3474512047b17864c55ad48b82721027a9ad0fec73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Balance</topic><topic>Bioindicators</topic><topic>Biology</topic><topic>Biomarkers</topic><topic>Chromosomes</topic><topic>Ethics</topic><topic>Female</topic><topic>Grip strength</topic><topic>Halcyon</topic><topic>Hand Strength - physiology</topic><topic>Humans</topic><topic>Leukocytes</topic><topic>Male</topic><topic>Mathematics</topic><topic>Medicine</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Physical Fitness - physiology</topic><topic>Polymerase chain reaction</topic><topic>Posture - physiology</topic><topic>Socioeconomic factors</topic><topic>Studies</topic><topic>Telomere Homeostasis - physiology</topic><topic>Telomeres</topic><topic>Walking</topic><topic>Walking - physiology</topic><topic>Yeast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gardner, Michael P</creatorcontrib><creatorcontrib>Martin-Ruiz, Carmen</creatorcontrib><creatorcontrib>Cooper, Rachel</creatorcontrib><creatorcontrib>Hardy, Rebecca</creatorcontrib><creatorcontrib>Sayer, Avan Aihie</creatorcontrib><creatorcontrib>Cooper, Cyrus</creatorcontrib><creatorcontrib>Deary, Ian J</creatorcontrib><creatorcontrib>Gallacher, John</creatorcontrib><creatorcontrib>Harris, Sarah E</creatorcontrib><creatorcontrib>Shiels, Paul G</creatorcontrib><creatorcontrib>Starr, John M</creatorcontrib><creatorcontrib>Kuh, Diana</creatorcontrib><creatorcontrib>von Zglinicki, Thomas</creatorcontrib><creatorcontrib>Ben-Shlomo, Yoav</creatorcontrib><creatorcontrib>Halcyon study team</creatorcontrib><creatorcontrib>the Halcyon study team</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gardner, Michael P</au><au>Martin-Ruiz, Carmen</au><au>Cooper, Rachel</au><au>Hardy, Rebecca</au><au>Sayer, Avan Aihie</au><au>Cooper, Cyrus</au><au>Deary, Ian J</au><au>Gallacher, John</au><au>Harris, Sarah E</au><au>Shiels, Paul G</au><au>Starr, John M</au><au>Kuh, Diana</au><au>von Zglinicki, Thomas</au><au>Ben-Shlomo, Yoav</au><au>Vina, Jose</au><aucorp>Halcyon study team</aucorp><aucorp>the Halcyon study team</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Telomere length and physical performance at older ages: an individual participant meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-07-26</date><risdate>2013</risdate><volume>8</volume><issue>7</issue><spage>e69526</spage><epage>e69526</epage><pages>e69526-e69526</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Telomeres are involved in cellular ageing and shorten with increasing age. If telomere length is a valuable biomarker of ageing, then telomere shortening should be associated with worse physical performance, an ageing trait, but evidence for such an association is lacking. The purpose of this study was to examine whether change in telomere length is associated with physical performance.
Using data from four UK adult cohorts (ages 53-80 years at baseline), we undertook cross-sectional and longitudinal analyses. We analysed each study separately and then used meta-analytic methods to pool the results. Physical performance was measured using walking and chair rise speed, standing balance time and grip strength. Telomere length was measured by quantitative real-time polymerase chain reaction (PCR) in whole blood at baseline and follow-up (time 1, time 2).
Total sample sizes in meta-analyses ranged from 1,217 to 3,707. There was little evidence that telomere length was associated with walking speed, balance or grip strength, though weak associations were seen with chair rise speed and grip strength at baseline (p = 0.02 and 0.01 respectively). Faster chair rise speed at follow-up, was associated with a smaller decline in telomere length between time 1 and time 2 (standardised coefficient per SD increase 0.061, 95% CI 0.006, 0.115, p = 0.03) but this was consistent with chance (p =0.08) after further adjustment.
Whereas shortening of leukocyte telomeres might be an important measure of cellular ageing, there is little evidence that it is a strong biomarker for physical performance.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23922731</pmid><doi>10.1371/journal.pone.0069526</doi><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1932-6203 |
ispartof | PloS one, 2013-07, Vol.8 (7), p.e69526-e69526 |
issn | 1932-6203 1932-6203 |
language | eng |
recordid | cdi_plos_journals_1428143585 |
source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
subjects | Adult Aged Aged, 80 and over Balance Bioindicators Biology Biomarkers Chromosomes Ethics Female Grip strength Halcyon Hand Strength - physiology Humans Leukocytes Male Mathematics Medicine Meta-analysis Middle Aged Physical Fitness - physiology Polymerase chain reaction Posture - physiology Socioeconomic factors Studies Telomere Homeostasis - physiology Telomeres Walking Walking - physiology Yeast |
title | Telomere length and physical performance at older ages: an individual participant meta-analysis |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T02%3A55%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Telomere%20length%20and%20physical%20performance%20at%20older%20ages:%20an%20individual%20participant%20meta-analysis&rft.jtitle=PloS%20one&rft.au=Gardner,%20Michael%20P&rft.aucorp=Halcyon%20study%20team&rft.date=2013-07-26&rft.volume=8&rft.issue=7&rft.spage=e69526&rft.epage=e69526&rft.pages=e69526-e69526&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0069526&rft_dat=%3Cproquest_plos_%3E3054537511%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1428143585&rft_id=info:pmid/23922731&rft_doaj_id=oai_doaj_org_article_400c9f8410bd4f88ab1f8dbf9beeca1a&rfr_iscdi=true |