Spatial relationships between GABAergic and glutamatergic synapses on the dendrites of distinct types of mouse retinal ganglion cells across development

Neuronal output requires a concerted balance between excitatory and inhibitory (I/E) input. Like other circuits, inhibitory synaptogenesis in the retina precedes excitatory synaptogenesis. How then do neurons attain their mature balance of I/E ratios despite temporal offset in synaptogenesis? To dir...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e69612-e69612
Hauptverfasser:	Bleckert, Adam, Parker, Edward D, Kang, Yunhee, Pancaroglu, Raika, Soto, Florentina, Lewis, Renate, Craig, Ann Marie, Wong, Rachel O L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amacrine Cells - cytology Amacrine Cells - metabolism Amacrine Cells - ultrastructure Animals Biology Brain research Dendrites Dendrites - metabolism Dendrites - ultrastructure Dimensional analysis Excitatory Postsynaptic Potentials Eye Fluorescence GABAergic Neurons - cytology GABAergic Neurons - metabolism GABAergic Neurons - ultrastructure Glutamatergic transmission Glutamic Acid - metabolism Inhibitory Postsynaptic Potentials Mice Mice, Transgenic Neurons Neurosciences Psychiatry Ratios Receptors Receptors, GABA-A - metabolism Retina Retinal Bipolar Cells - cytology Retinal Bipolar Cells - metabolism Retinal Bipolar Cells - ultrastructure Retinal ganglion cells Retinal Ganglion Cells - cytology Retinal Ganglion Cells - metabolism Retinal Ganglion Cells - ultrastructure Spatial distribution Staining and Labeling Synapses Synapses - metabolism Synapses - ultrastructure Synaptogenesis Thy-1 Antigens - metabolism Transgenic mice γ-Aminobutyric acid A receptors
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