Cytosolic Phospholipase A2α and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation

The role of Group IVA cytosolic phospholipase A2 (cPLA2α) activation in regulating macrophage transcriptional responses to Candida albicans infection was investigated. cPLA2α releases arachidonic acid for the production of eicosanoids. In mouse resident peritoneal macrophages, prostacyclin, prostagl...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e69002
Hauptverfasser:	Suram, Saritha, Silveira, Lori J., Mahaffey, Spencer, Brown, Gordon D., Bonventre, Joseph V., Williams, David L., Gow, Neil A. R., Bratton, Donna L., Murphy, Robert C., Leslie, Christina C.
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCA1 protein Arachidonic acid ATP-binding protein Autocrine signalling Candida albicans CD40 antigen Cell activation Connexin 43 Cyclic AMP Cyclooxygenase-1 Cyclooxygenase-2 Cytokines DNA microarrays Eicosanoids Enzyme inhibitors Fungal infections Gap junctions Gene expression Genes Inflammation Interferon regulatory factor 1 Interferon regulatory factor 4 Interleukin 1 Interleukin 10 Kinases Laboratories Macrophages Medical research Neutrophils Pattern recognition Pediatrics Peritoneum Phospholipase Phospholipase A2 Prostaglandins Rodents Signal transduction γ-Interferon
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