Rescue of amyloid-Beta-induced inhibition of nicotinic acetylcholine receptors by a peptide homologous to the nicotine binding domain of the alpha 7 subtype

Alzheimer's disease (AD) is characterized by brain accumulation of the neurotoxic amyloid-β peptide (Aβ) and by loss of cholinergic neurons and nicotinic acetylcholine receptors (nAChRs). Recent evidence indicates that memory loss and cognitive decline in AD correlate better with the amount of...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e67194
Hauptverfasser:	Nery, Arthur A, Magdesian, Margaret H, Trujillo, Cleber A, Sathler, Luciana B, Juliano, Maria A, Juliano, Luiz, Ulrich, Henning, Ferreira, Sergio T
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (nicotinic) Advertising executives Alanine alpha7 Nicotinic Acetylcholine Receptor - chemistry alpha7 Nicotinic Acetylcholine Receptor - metabolism Alzheimer's disease Alzheimers disease Amino Acid Sequence Amino acids Amyloid beta-Peptides - pharmacology Animals Binding Binding sites Biochemistry Biology Biophysics Blocking Brain Carbachol Cocaine Cognitive ability Drugs Gene Expression Regulation - drug effects HEK293 Cells Homology Humans Inhibition Intelligence Ligands Medicine Memory Mutagenesis Neurodegenerative diseases Neurons Neurotoxicity Nicotine Nicotine - metabolism Nicotinic Antagonists - pharmacology Oligopeptides - chemistry Oligopeptides - pharmacology PC12 Cells Peptide Fragments - pharmacology Peptides Phage display Phages Pheochromocytoma cells Protein Structure, Tertiary Rats Receptors Scanning mutagenesis β-Amyloid
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