In vivo neutralization of α-cobratoxin with high-affinity llama single-domain antibodies (VHHs) and a VHH-Fc antibody

Small recombinant antibody fragments (e.g. scFvs and VHHs), which are highly tissue permeable, are being investigated for antivenom production as conventional antivenoms consisting of IgG or F(ab')2 antibody fragments do not effectively neutralize venom toxins located in deep tissues. However,...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e69495
Hauptverfasser:	Richard, Gabrielle, Meyers, Ashley J, McLean, Michael D, Arbabi-Ghahroudi, Mehdi, MacKenzie, Roger, Hall, J Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Amino Acid Sequence Animals Antibodies Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - genetics Antibodies, Neutralizing - immunology Antibody Affinity Antigens Antivenom Binding sites Biology Camelids, New World Cloning Cobra Neurotoxin Proteins - immunology Councils Elapid Venoms - immunology Environmental science Enzymes Fragmentation Fragments Half-Life Humans Immune system Immunity, Humoral Immunization Immunogenicity Immunoglobulin Fc Fragments - chemistry Immunoglobulin Fc Fragments - genetics Immunoglobulin Fc Fragments - immunology Immunoglobulin G Immunoglobulins Immunology In vivo methods and tests Kinetics Laboratories Lethality Male Mice Molecular Sequence Data Naja kaouthia Nanobodies Neutralization Penetration Phages Purification Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Single-Domain Antibodies - chemistry Single-Domain Antibodies - genetics Single-Domain Antibodies - immunology Snake bites Tissues Toxins Venom Venom toxins
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