Knockdown of CDKN1C (p57(kip2)) and PHLDA2 results in developmental changes in bovine pre-implantation embryos

Imprinted genes have been implicated in early embryonic, placental, and neonatal development and alterations in expression levels of these genes can lead to growth abnormalities and embryonic lethality. However, little is known about the functions of bovine imprinted genes during the pre-implantatio...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e69490-e69490
Hauptverfasser:	Driver, Ashley M, Huang, Wen, Kropp, Jenna, Peñagaricano, Francisco, Khatib, Hasan
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Animal sciences Animals Apoptosis Biology Blastocysts Cattle Cdkn1c protein Cell cycle Comparative analysis Cyclin-Dependent Kinase Inhibitor p57 - deficiency Cyclin-Dependent Kinase Inhibitor p57 - genetics Degeneration Developmental stages DNA methylation Embryo Implantation - genetics Embryogenesis Embryonic development Embryos Functional analysis Gene expression Gene Knockdown Techniques Genes Genomes Genomics Implantation Injection Insulin-like growth factor II Insulin-like growth factor II receptors Kinases Lethality Lipid metabolism Metabolism Neonates Nuclear Proteins - deficiency Nuclear Proteins - genetics Peg3 protein Physiological aspects Placenta Ribonucleic acid RNA RNA sequencing RNA, Small Interfering - genetics Signaling siRNA Steroids (Organic compounds) Success Transcriptome Ubiquitin-protein ligase Zygotes
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