Effect of epicatechin against radiation-induced oral mucositis: in vitro and in vivo study

Radiation-induced oral mucositis limits the delivery of high-dose radiation to head and neck cancer. This study investigated the effectiveness of epicatechin (EC), a component of green tea extracts, on radiation-induced oral mucositis in vitro and in vivo. The effect of EC on radiation-induced cytot...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e69151
Hauptverfasser:	Shin, Yoo Seob, Shin, Hyang Ae, Kang, Sung Un, Kim, Jang Hee, Oh, Young-Taek, Park, Keun Hyung, Kim, Chul-Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analysis of Variance Animals Apoptosis Apoptosis - drug effects Biocompatibility Biology Blotting, Western Cancer Caspase Caspase-3 Catechin - pharmacology Catechin - therapeutic use Cytotoxicity Epicatechin Experimental design Female Fluorescein-5-isothiocyanate Green tea Head Head & neck cancer Head and neck cancer Head and Neck Neoplasms - radiotherapy Health aspects Humans Immunohistochemistry In Situ Nick-End Labeling In vivo methods and tests Irradiation JNK protein Keratinocytes Keratinocytes - drug effects Kinases Medicine Membrane potential Membrane Potential, Mitochondrial - drug effects Microscopy, Fluorescence Mitochondria Mucosa Mucositis Oral administration Oral cavity Otolaryngology Oxygen Physics Propidium Radiation Radiation (Physics) Radiation dosage Radiation effects Radiotherapy - adverse effects Rats Rats, Sprague-Dawley Reactive oxygen species Reactive Oxygen Species - metabolism Signal transduction Signal Transduction - drug effects Signaling Staining Stomatitis Stomatitis - drug therapy Stomatitis - etiology Survival Tea Toxicity
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