The identification of trans-acting factors that regulate the expression of GDF5 via the osteoarthritis susceptibility SNP rs143383

rs143383 is a C to T transition SNP located in the 5'untranslated region (5'UTR) of the growth differentiation factor 5 gene GDF5. The T allele of the SNP is associated with increased risk of osteoarthritis (OA) in Europeans and in Asians. This susceptibility is mediated by the T allele pr...

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Veröffentlicht in:	PLoS genetics 2013-06, Vol.9 (6), p.e1003557-e1003557
Hauptverfasser:	Syddall, Catherine M, Reynard, Louise N, Young, David A, Loughlin, John
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions - genetics Alleles Allelic Imbalance - genetics Arthritis Biology Biomedical research Competition Disease Disease susceptibility DNA-Binding Proteins Experiments Gene expression Gene Expression Regulation Genetic aspects Genetic Predisposition to Disease Genetics Growth Differentiation Factor 5 - genetics Growth Differentiation Factor 5 - metabolism Health aspects Humans Joint surgery Mass spectrometry Medical research Medicine Mortality Nuclear Proteins - genetics Nuclear Proteins - metabolism Osteoarthritis Osteoarthritis - genetics Osteoarthritis - metabolism Physiological aspects Polymorphism, Single Nucleotide - genetics RNA Interference Sp1 Transcription Factor - genetics Sp1 Transcription Factor - metabolism Sp3 Transcription Factor - genetics Sp3 Transcription Factor - metabolism Studies Transcription Factors
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