Adding diverse noncanonical backbones to rosetta: enabling peptidomimetic design

Peptidomimetics are classes of molecules that mimic structural and functional attributes of polypeptides. Peptidomimetic oligomers can frequently be synthesized using efficient solid phase synthesis procedures similar to peptide synthesis. Conformationally ordered peptidomimetic oligomers are findin...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e67051
Hauptverfasser:	Drew, Kevin, Renfrew, P Douglas, Craven, Timothy W, Butterfoss, Glenn L, Chou, Fang-Chieh, Lyskov, Sergey, Bullock, Brooke N, Watkins, Andrew, Labonte, Jason W, Pacella, Michael, Kilambi, Krishna Praneeth, Leaver-Fay, Andrew, Kuhlman, Brian, Gray, Jeffrey J, Bradley, Philip, Kirshenbaum, Kent, Arora, Paramjit S, Das, Rhiju, Bonneau, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Amino acids Analysis Applications programs Backbone Biochemistry Bioengineering Biology Cancer therapies Carbon Chains Chemical synthesis Chemistry Communities Computational Biology - methods Design Engineering Genomics Helices Hydrogen Hydrogen bonds MDM2 protein Medical research Oligomers Oligosaccharides p53 Protein Peptide synthesis Peptides Peptidomimetics Peptidomimetics - chemistry Polymers Polypeptides Protein Engineering Protein interaction Protein Structure, Tertiary Protein-protein interactions Proteins Quantum mechanics Scaffolds Science Software Solid phase methods Solid phase synthesis Structure-function relationships Tumor proteins Web applications
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