Gemcitabine eliminates double minute chromosomes from human ovarian cancer cells

Double minute chromosomes are cytogenetic manifestations of gene amplification frequently seen in cancer cells. Genes amplified on double minute chromosomes include oncogenes and multi-drug resistant genes. These genes encode proteins which contribute to cancer formation, cancer progression, and dev...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e71988
Hauptverfasser:	Yu, Lisa, Zhao, Yan, Quan, Chao, Ji, Wei, Zhu, Jing, Huang, Yun, Guan, Rongwei, Sun, Donglin, Jin, Yan, Meng, Xiangning, Zhang, Chunyu, Yu, Yang, Bai, Jing, Sun, Wenjing, Fu, Songbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amplification Antineoplastic Agents - pharmacology Biological effects Biology Bladder cancer Breast cancer Cancer Cancer cells Cancer genetics Cancer therapies Cancer treatment Cell cycle Cell Line, Tumor Cell Proliferation - drug effects Chromatin Chromosomes Colorectal cancer Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Double minute chromosomes Drug development Drug resistance Drugs Entrapment Enzymes Eukaryotic Translation Initiation Factor 5A Female Gemcitabine Gene amplification Gene Amplification - drug effects Genes Genetic aspects Health risk assessment Higher education Histones - metabolism Humans Hydroxyurea Hydroxyurea - pharmacology In Situ Hybridization, Fluorescence Kinases Laboratories Lung cancer Malignancy Medicine Micronuclei Micronuclei, Chromosome-Defective - drug effects Multidrug resistance Myeloid Cell Leukemia Sequence 1 Protein - genetics N-Myc Proto-Oncogene Protein Nuclear Proteins - genetics Oncogene Proteins - genetics Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Peptide Initiation Factors - genetics Proteins Real-Time Polymerase Chain Reaction Ribonucleotide reductase RNA-Binding Proteins - genetics
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