Analysis of mutations in Neurospora crassa ERMES components reveals specific functions related to β-barrel protein assembly and maintenance of mitochondrial morphology

The endoplasmic reticulum mitochondria encounter structure (ERMES) tethers the er to mitochondria and contains four structural components: Mmm1, Mdm12, Mdm10, and Mmm2 (Mdm34). The Gem1 protein may play a role in regulating ERMES function. Saccharomyces cerevisiae and Neurospora crassa strains lacki...

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Veröffentlicht in:	PloS one 2013-08, Vol.8 (8), p.e71837-e71837
Hauptverfasser:	Wideman, Jeremy G, Lackey, Sebastian W K, Srayko, Martin A, Norton, Kacie A, Nargang, Frank E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Assembly Biology Biosynthesis Defects Dimers DNA Mutational Analysis Endoplasmic reticulum Endoplasmic Reticulum - genetics Endoplasmic Reticulum - metabolism Fungi Membrane proteins Microscopy Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondrial DNA Mitochondrial Membrane Transport Proteins - chemistry Mitochondrial Membrane Transport Proteins - genetics Mitochondrial Membrane Transport Proteins - metabolism Mitochondrial Membranes - metabolism Mitochondrial Membranes - physiology Molecular Sequence Data Morphology Mutation Mutation - physiology N-Terminus Neurospora Neurospora crassa Neurospora crassa - genetics Neurospora crassa - metabolism Organelle Shape - genetics Organisms, Genetically Modified Protein Multimerization - genetics Protein Multimerization - physiology Protein transport Proteins Saccharomyces cerevisiae Sequence Homology, Amino Acid Structure-Activity Relationship Studies Tethers
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