Iduronic acid in chondroitin/dermatan sulfate affects directional migration of aortic smooth muscle cells

Aortic smooth muscle cells produce chondroitin/dermatan sulfate (CS/DS) proteoglycans that regulate extracellular matrix organization and cell behavior in normal and pathological conditions. A unique feature of CS/DS proteoglycans is the presence of iduronic acid (IdoA), catalyzed by two DS epimeras...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e66704-e66704
Hauptverfasser:	Bartolini, Barbara, Thelin, Martin A, Svensson, Lena, Ghiselli, Giancarlo, van Kuppevelt, Toin H, Malmström, Anders, Maccarana, Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adhesion Animals Aorta Aorta - cytology Aorta - metabolism Arteriosclerosis Atherosclerosis Basic Medicine Biology Cancer Carbohydrate Epimerases - deficiency Carbohydrate Epimerases - genetics Carbohydrate Epimerases - metabolism Cell Adhesion Cell and Molecular Biology Cell Movement Cell surface Cell- och molekylärbiologi Chemistry Chondroitin Sulfates - chemistry Dermatan Sulfate - chemistry Epimerase Extracellular matrix Fibroblasts Focal adhesion kinase Focal Adhesion Kinase 1 - genetics Focal Adhesion Kinase 1 - metabolism Focal Adhesions Gene Expression Genetic aspects Growth factors Iduronic Acid - chemistry Iduronic Acid - metabolism Kinases Laboratories Ligands Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Mice Mice, Knockout Morphology Muscles Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - metabolism Physiological aspects Primary Cell Culture Protein kinases Proteoglycans Rodents Science Smooth muscle Sulfates
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