Clinical and epidemiologic characteristics of norovirus GII.4 Sydney during winter 2012-13 in Beijing, China following its global emergence
Limited information is available on the molecular epidemiology of GII.4 Sydney-associated diarrhea in China in the winter of 2012-13 during the global epidemic associated with the emergence of GII.4 Sydney. Fecal specimens collected from 171 diarrhea outpatients (one from each) between late October...
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| Veröffentlicht in: | PloS one 2013-08, Vol.8 (8), p.e71483-e71483 |
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| creator | Mai, Huan Jin, Miao Guo, Xiaolin Liu, Jian Liu, Ning Cong, Xu Gao, Yan Wei, Lai |
| description | Limited information is available on the molecular epidemiology of GII.4 Sydney-associated diarrhea in China in the winter of 2012-13 during the global epidemic associated with the emergence of GII.4 Sydney.
Fecal specimens collected from 171 diarrhea outpatients (one from each) between late October 2012 and the middle of March 2013 were examined for NoV by reverse transcription-polymerase chain reaction and sequences corresponding to both the NoV partial polymerase and partial capsid regions were analyzed phylogenetically. Clinical characteristics of GII.4 Sydney cases versus other NoV-positive cases detected in a previous study were compared statistically.
Twenty-six (15.2%, 26/171) outpatients with diarrhea were infected with NoV. Twenty-two of the 26 (84.6%) identified NoV strains clustered into GII.4 Sydney. There was a significant difference in symptoms of fever (χ(2), P |
| doi_str_mv | 10.1371/journal.pone.0071483 |
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Fecal specimens collected from 171 diarrhea outpatients (one from each) between late October 2012 and the middle of March 2013 were examined for NoV by reverse transcription-polymerase chain reaction and sequences corresponding to both the NoV partial polymerase and partial capsid regions were analyzed phylogenetically. Clinical characteristics of GII.4 Sydney cases versus other NoV-positive cases detected in a previous study were compared statistically.
Twenty-six (15.2%, 26/171) outpatients with diarrhea were infected with NoV. Twenty-two of the 26 (84.6%) identified NoV strains clustered into GII.4 Sydney. There was a significant difference in symptoms of fever (χ(2), P<0.05 ), abdominal pain (χ(2), P<0.05 ) and diarrhea frequency (Mann-Whitney U test, P<0.05) between the GII.4 Sydney case group and other NoV-positive case group.
The new NoV variant, GII.4 Sydney, has been circulating in Beijing, China and became the predominant strain in the winter of 2012-13. GII.4 Sydney causes severe fever, abdominal pain and higher diarrhea frequency clinically compared to other NoV infections.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0071483</identifier><identifier>PMID: 23977050</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Biology ; Caliciviridae Infections - epidemiology ; Caliciviridae Infections - virology ; Capsid ; China - epidemiology ; Consent ; Diarrhea ; Disease control ; Emergence ; Epidemics ; Epidemiology ; Ethics ; Female ; Fever ; Gastroenteritis - epidemiology ; Gastroenteritis - virology ; Genotype ; Genotype & phenotype ; Health aspects ; Hepatology ; Hospitals ; Humans ; Infectious diseases ; Laboratories ; Male ; Medicine ; Middle Aged ; Molecular Sequence Data ; Norovirus - genetics ; Norovirus - isolation & purification ; Norovirus - physiology ; Outpatients - statistics & numerical data ; Pain ; Pandemics - statistics & numerical data ; Phylogeny ; Polymerase chain reaction ; Reverse transcription ; Seasons ; Sequence Analysis, DNA ; Surveillance ; Virology ; Winter</subject><ispartof>PloS one, 2013-08, Vol.8 (8), p.e71483-e71483</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Mai et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Mai et al 2013 Mai et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-b28cbc423cd4d706f76944120d4ce47f96b97247092ae853aafefe7e027b95153</citedby><cites>FETCH-LOGICAL-c758t-b28cbc423cd4d706f76944120d4ce47f96b97247092ae853aafefe7e027b95153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745450/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745450/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23977050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Khudyakov, Yury E.</contributor><creatorcontrib>Mai, Huan</creatorcontrib><creatorcontrib>Jin, Miao</creatorcontrib><creatorcontrib>Guo, Xiaolin</creatorcontrib><creatorcontrib>Liu, Jian</creatorcontrib><creatorcontrib>Liu, Ning</creatorcontrib><creatorcontrib>Cong, Xu</creatorcontrib><creatorcontrib>Gao, Yan</creatorcontrib><creatorcontrib>Wei, Lai</creatorcontrib><title>Clinical and epidemiologic characteristics of norovirus GII.4 Sydney during winter 2012-13 in Beijing, China following its global emergence</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Limited information is available on the molecular epidemiology of GII.4 Sydney-associated diarrhea in China in the winter of 2012-13 during the global epidemic associated with the emergence of GII.4 Sydney.
Fecal specimens collected from 171 diarrhea outpatients (one from each) between late October 2012 and the middle of March 2013 were examined for NoV by reverse transcription-polymerase chain reaction and sequences corresponding to both the NoV partial polymerase and partial capsid regions were analyzed phylogenetically. Clinical characteristics of GII.4 Sydney cases versus other NoV-positive cases detected in a previous study were compared statistically.
Twenty-six (15.2%, 26/171) outpatients with diarrhea were infected with NoV. Twenty-two of the 26 (84.6%) identified NoV strains clustered into GII.4 Sydney. There was a significant difference in symptoms of fever (χ(2), P<0.05 ), abdominal pain (χ(2), P<0.05 ) and diarrhea frequency (Mann-Whitney U test, P<0.05) between the GII.4 Sydney case group and other NoV-positive case group.
The new NoV variant, GII.4 Sydney, has been circulating in Beijing, China and became the predominant strain in the winter of 2012-13. GII.4 Sydney causes severe fever, abdominal pain and higher diarrhea frequency clinically compared to other NoV infections.</description><subject>Adult</subject><subject>Biology</subject><subject>Caliciviridae Infections - epidemiology</subject><subject>Caliciviridae Infections - virology</subject><subject>Capsid</subject><subject>China - epidemiology</subject><subject>Consent</subject><subject>Diarrhea</subject><subject>Disease control</subject><subject>Emergence</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Ethics</subject><subject>Female</subject><subject>Fever</subject><subject>Gastroenteritis - epidemiology</subject><subject>Gastroenteritis - virology</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Health aspects</subject><subject>Hepatology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Norovirus - genetics</subject><subject>Norovirus - isolation & purification</subject><subject>Norovirus - physiology</subject><subject>Outpatients - statistics & numerical data</subject><subject>Pain</subject><subject>Pandemics - statistics & numerical data</subject><subject>Phylogeny</subject><subject>Polymerase chain reaction</subject><subject>Reverse transcription</subject><subject>Seasons</subject><subject>Sequence Analysis, DNA</subject><subject>Surveillance</subject><subject>Virology</subject><subject>Winter</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk21rFDEQxxdRbK1-A9GAIAremcfN7huhHloPCgWrvg3Z7OxejlxyTXZb7zP4pc2119KTvpAEEia_-U9mkimKlwRPCZPk4zKM0Ws3XQcPU4wl4RV7VBySmtFJSTF7fG9_UDxLaYmxYFVZPi0OKKulxAIfFn9mznprtEPatwjWtoWVDS701iCz0FGbAaJNgzUJhQ75EMOljWNCJ_P5lKPzTethg9oxWt-jK-szjSgmdEIYsh59BrvMJx_QbGG9Rl1wLlxtUTsk1LvQ5MCwgtiDN_C8eNJpl-DFbj0qfn798mP2bXJ6djKfHZ9OjBTVMGloZRrDKTMtbyUuO1nWnBOKW26Ay64um1pSLnFNNVSCad1BBxIwlU0tiGBHxesb3bULSe3qmBThVPC6klWdifkN0Qa9VOtoVzpuVNBWXRtC7JWOuSYOVFeBMFXLGkNyzEo0TJTQEjCVNHVjZNb6tIs2NitoDfgharcnun_i7UL14VIxyQUXOAu82wnEcDFCGtTKJgPOaQ9hvL53RSURkmX0zT_ow9ntqF7nBKzvQo5rtqLqOKdARZ5brekDVB7bH2Lyp-tstu85vN9zyMwAv4dejymp-fn3_2fPfu2zb--xC9BuWKTgxsEGn_ZBfgOaGFKK0N0VmWC17Znbaqhtz6hdz2S3V_cf6M7ptknYX0sHEZc</recordid><startdate>20130816</startdate><enddate>20130816</enddate><creator>Mai, Huan</creator><creator>Jin, Miao</creator><creator>Guo, Xiaolin</creator><creator>Liu, Jian</creator><creator>Liu, Ning</creator><creator>Cong, Xu</creator><creator>Gao, Yan</creator><creator>Wei, Lai</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130816</creationdate><title>Clinical and epidemiologic characteristics of norovirus GII.4 Sydney during winter 2012-13 in Beijing, China following its global emergence</title><author>Mai, Huan ; Jin, Miao ; Guo, Xiaolin ; Liu, Jian ; Liu, Ning ; Cong, Xu ; Gao, Yan ; Wei, Lai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-b28cbc423cd4d706f76944120d4ce47f96b97247092ae853aafefe7e027b95153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Biology</topic><topic>Caliciviridae Infections - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mai, Huan</au><au>Jin, Miao</au><au>Guo, Xiaolin</au><au>Liu, Jian</au><au>Liu, Ning</au><au>Cong, Xu</au><au>Gao, Yan</au><au>Wei, Lai</au><au>Khudyakov, Yury E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and epidemiologic characteristics of norovirus GII.4 Sydney during winter 2012-13 in Beijing, China following its global emergence</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-08-16</date><risdate>2013</risdate><volume>8</volume><issue>8</issue><spage>e71483</spage><epage>e71483</epage><pages>e71483-e71483</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Limited information is available on the molecular epidemiology of GII.4 Sydney-associated diarrhea in China in the winter of 2012-13 during the global epidemic associated with the emergence of GII.4 Sydney.
Fecal specimens collected from 171 diarrhea outpatients (one from each) between late October 2012 and the middle of March 2013 were examined for NoV by reverse transcription-polymerase chain reaction and sequences corresponding to both the NoV partial polymerase and partial capsid regions were analyzed phylogenetically. Clinical characteristics of GII.4 Sydney cases versus other NoV-positive cases detected in a previous study were compared statistically.
Twenty-six (15.2%, 26/171) outpatients with diarrhea were infected with NoV. Twenty-two of the 26 (84.6%) identified NoV strains clustered into GII.4 Sydney. There was a significant difference in symptoms of fever (χ(2), P<0.05 ), abdominal pain (χ(2), P<0.05 ) and diarrhea frequency (Mann-Whitney U test, P<0.05) between the GII.4 Sydney case group and other NoV-positive case group.
The new NoV variant, GII.4 Sydney, has been circulating in Beijing, China and became the predominant strain in the winter of 2012-13. GII.4 Sydney causes severe fever, abdominal pain and higher diarrhea frequency clinically compared to other NoV infections.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23977050</pmid><doi>10.1371/journal.pone.0071483</doi><tpages>e71483</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biology Caliciviridae Infections - epidemiology Caliciviridae Infections - virology Capsid China - epidemiology Consent Diarrhea Disease control Emergence Epidemics Epidemiology Ethics Female Fever Gastroenteritis - epidemiology Gastroenteritis - virology Genotype Genotype & phenotype Health aspects Hepatology Hospitals Humans Infectious diseases Laboratories Male Medicine Middle Aged Molecular Sequence Data Norovirus - genetics Norovirus - isolation & purification Norovirus - physiology Outpatients - statistics & numerical data Pain Pandemics - statistics & numerical data Phylogeny Polymerase chain reaction Reverse transcription Seasons Sequence Analysis, DNA Surveillance Virology Winter |
| title | Clinical and epidemiologic characteristics of norovirus GII.4 Sydney during winter 2012-13 in Beijing, China following its global emergence |
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