A high frequency of circulating th22 and th17 cells in patients with new onset graves' disease
T-helper (Th) 22 and Th17 cells are involved in the pathogenesis of autoimmune diseases. However, their roles in the pathogenesis of Graves'disease (GD) are unclear. This study is aimed at examining the frequency of peripheral blood Th22, Th17, and Th1 cells and the levels of plasma IL-22, IL-1...
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| description | T-helper (Th) 22 and Th17 cells are involved in the pathogenesis of autoimmune diseases. However, their roles in the pathogenesis of Graves'disease (GD) are unclear. This study is aimed at examining the frequency of peripheral blood Th22, Th17, and Th1 cells and the levels of plasma IL-22, IL-17, and IFN-γ in patients with GD. A total of 27 patients with new onset GD and 27 gender- and age-matched healthy controls (HC) were examined for the frequency of peripheral blood Th22, Th17, and IFN-γ cells by flow cytometry. The concentrations of plasma IL-22, IL-17, and IFN-γ were examined by enzyme-linked immunosorbent assay. The levels of serum TSHR antibodies (A-TSHR), free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) were examined by radioimmunoassay and chemiluminescent assay, respectively. The levels of serum TSAb were examined by enzyme-linked immunosorbent assay. In comparison with those in the HC, significantly elevated percentages of Th22 and Th17 cells, but not Th1 cells, and increased levels of plasma IL-22 and IL-17, but not IFN-γ, were detected in GD patients (P |
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However, their roles in the pathogenesis of Graves'disease (GD) are unclear. This study is aimed at examining the frequency of peripheral blood Th22, Th17, and Th1 cells and the levels of plasma IL-22, IL-17, and IFN-γ in patients with GD. A total of 27 patients with new onset GD and 27 gender- and age-matched healthy controls (HC) were examined for the frequency of peripheral blood Th22, Th17, and IFN-γ cells by flow cytometry. The concentrations of plasma IL-22, IL-17, and IFN-γ were examined by enzyme-linked immunosorbent assay. The levels of serum TSHR antibodies (A-TSHR), free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) were examined by radioimmunoassay and chemiluminescent assay, respectively. The levels of serum TSAb were examined by enzyme-linked immunosorbent assay. In comparison with those in the HC, significantly elevated percentages of Th22 and Th17 cells, but not Th1 cells, and increased levels of plasma IL-22 and IL-17, but not IFN-γ, were detected in GD patients (P<0.0001, for both). The percentages of both Th22 and Th17 cells and the levels of plasma IL-22 and IL-17 were correlated positively with the levels of serum TSAb in GD patients (r = 0.7944, P<0.0001; r = 0.8110, P<0.0001; r = 0.7101, p<0.0001; r = 0.7407, p<0.0001, respectively). Th22 and Th17 cells may contribute to the pathogenesis of GD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0068446</identifier><identifier>PMID: 23874630</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Analysis ; Antibodies ; Autoimmune diseases ; Blood ; CD4-Positive T-Lymphocytes - immunology ; Chemiluminescence ; Cytokines ; Cytometry ; Disease ; Enzyme-linked immunosorbent assay ; Enzymes ; Female ; Flow cytometry ; Gender ; Graves Disease - blood ; Graves Disease - immunology ; Helper cells ; Humans ; Hyperthyroidism ; Interferon ; Interferon-gamma - blood ; Interferon-gamma - immunology ; Interleukin 17 ; Interleukin 22 ; Interleukin-17 - blood ; Interleukin-17 - immunology ; Interleukins - blood ; Interleukins - immunology ; Laboratories ; Lymphocytes ; Lymphocytes T ; Male ; Medicine ; Middle Aged ; Pathogenesis ; Patients ; Peripheral blood ; Psoriasis ; Radioimmunoassay ; Rheumatoid arthritis ; Th1 Cells - immunology ; Th17 Cells - immunology ; Thyroid ; Thyroid gland ; Thyroid hormones ; Thyroid-stimulating hormone ; Thyroid-stimulating hormone receptors ; Thyrotropin - blood ; Thyrotropin - immunology ; Thyroxine ; Thyroxine - blood ; Thyroxine - immunology ; Triiodothyronine ; Triiodothyronine - blood ; Triiodothyronine - immunology ; Young Adult ; Zoonoses ; γ-Interferon</subject><ispartof>PloS one, 2013-07, Vol.8 (7), p.e68446-e68446</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Peng et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Peng et al 2013 Peng et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-d543219d632d2ebaaf3bfb7ae9dc412fddfff5178bc82ad62c74c41113520b653</citedby><cites>FETCH-LOGICAL-c692t-d543219d632d2ebaaf3bfb7ae9dc412fddfff5178bc82ad62c74c41113520b653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708941/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708941/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23874630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Fang, Deyu</contributor><creatorcontrib>Peng, Di</creatorcontrib><creatorcontrib>Xu, Bingchuan</creatorcontrib><creatorcontrib>Wang, Ye</creatorcontrib><creatorcontrib>Guo, Hui</creatorcontrib><creatorcontrib>Jiang, Yanfang</creatorcontrib><title>A high frequency of circulating th22 and th17 cells in patients with new onset graves' disease</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>T-helper (Th) 22 and Th17 cells are involved in the pathogenesis of autoimmune diseases. However, their roles in the pathogenesis of Graves'disease (GD) are unclear. This study is aimed at examining the frequency of peripheral blood Th22, Th17, and Th1 cells and the levels of plasma IL-22, IL-17, and IFN-γ in patients with GD. A total of 27 patients with new onset GD and 27 gender- and age-matched healthy controls (HC) were examined for the frequency of peripheral blood Th22, Th17, and IFN-γ cells by flow cytometry. The concentrations of plasma IL-22, IL-17, and IFN-γ were examined by enzyme-linked immunosorbent assay. The levels of serum TSHR antibodies (A-TSHR), free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) were examined by radioimmunoassay and chemiluminescent assay, respectively. The levels of serum TSAb were examined by enzyme-linked immunosorbent assay. In comparison with those in the HC, significantly elevated percentages of Th22 and Th17 cells, but not Th1 cells, and increased levels of plasma IL-22 and IL-17, but not IFN-γ, were detected in GD patients (P<0.0001, for both). The percentages of both Th22 and Th17 cells and the levels of plasma IL-22 and IL-17 were correlated positively with the levels of serum TSAb in GD patients (r = 0.7944, P<0.0001; r = 0.8110, P<0.0001; r = 0.7101, p<0.0001; r = 0.7407, p<0.0001, respectively). Th22 and Th17 cells may contribute to the pathogenesis of GD.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis</subject><subject>Antibodies</subject><subject>Autoimmune diseases</subject><subject>Blood</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Chemiluminescence</subject><subject>Cytokines</subject><subject>Cytometry</subject><subject>Disease</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzymes</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>Gender</subject><subject>Graves Disease - blood</subject><subject>Graves Disease - immunology</subject><subject>Helper cells</subject><subject>Humans</subject><subject>Hyperthyroidism</subject><subject>Interferon</subject><subject>Interferon-gamma - blood</subject><subject>Interferon-gamma - immunology</subject><subject>Interleukin 17</subject><subject>Interleukin 22</subject><subject>Interleukin-17 - blood</subject><subject>Interleukin-17 - immunology</subject><subject>Interleukins - blood</subject><subject>Interleukins - immunology</subject><subject>Laboratories</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Peripheral blood</subject><subject>Psoriasis</subject><subject>Radioimmunoassay</subject><subject>Rheumatoid arthritis</subject><subject>Th1 Cells - immunology</subject><subject>Th17 Cells - immunology</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid hormones</subject><subject>Thyroid-stimulating hormone</subject><subject>Thyroid-stimulating hormone receptors</subject><subject>Thyrotropin - blood</subject><subject>Thyrotropin - immunology</subject><subject>Thyroxine</subject><subject>Thyroxine - blood</subject><subject>Thyroxine - immunology</subject><subject>Triiodothyronine</subject><subject>Triiodothyronine - blood</subject><subject>Triiodothyronine - immunology</subject><subject>Young Adult</subject><subject>Zoonoses</subject><subject>γ-Interferon</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tq3DAQhk1padK0b1BaQaGHi93q4ONNIYQeFgKBni4rZGlka_FKG0lOmrevtuuEdclFMdhC880_0u-ZLHtO8JKwirxfu9FbMSy3zsIS47LO8_JBdkwaRhclxezhwfooexLCGuOC1WX5ODuirK7ykuHj7Ncp6k3XI-3hcgQrb5DTSBovx0FEYzsUe0qRsCotSIUkDENAxqJtioKNAV2b2CML18jZABF1XlxBeIOUCSACPM0eaTEEeDZ9T7Ifnz5-P_uyOL_4vDo7PV_IsqFxoYqcUdKoklFFoRVCs1a3lYBGyZxQrZTWuiBV3cqaClVSWeUpQAgrKG7Lgp1kL_e628EFPlkTOGFNUzCGaZWI1Z5QTqz51puN8DfcCcP_bjjfceGjkQPwFjOsCEBbCJzLuhCsIBRX6a1qDBInrQ9TtbHdgJLJCC-Gmeg8Yk3PO3fFWYXrJidJ4O0k4F2yPUS-MWHnrbDgxnTudLfkBWF1Ql_9g95_u4nqRLqAsdqlunInyk_zqma0SHUTtbyHSo-CjZGpj7RJ-7OEd7OExET4HTsxhsBX377-P3vxc86-PmB7EEPsgxvGaFIXzcF8D0rvQvCg70wmmO_G4NYNvhsDPo1BSntx-IPukm77nv0B4NIBWg</recordid><startdate>20130711</startdate><enddate>20130711</enddate><creator>Peng, Di</creator><creator>Xu, Bingchuan</creator><creator>Wang, Ye</creator><creator>Guo, Hui</creator><creator>Jiang, Yanfang</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130711</creationdate><title>A high frequency of circulating th22 and th17 cells in patients with new onset graves' disease</title><author>Peng, Di ; Xu, Bingchuan ; Wang, Ye ; Guo, Hui ; Jiang, Yanfang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-d543219d632d2ebaaf3bfb7ae9dc412fddfff5178bc82ad62c74c41113520b653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis</topic><topic>Antibodies</topic><topic>Autoimmune diseases</topic><topic>Blood</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>Chemiluminescence</topic><topic>Cytokines</topic><topic>Cytometry</topic><topic>Disease</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Enzymes</topic><topic>Female</topic><topic>Flow cytometry</topic><topic>Gender</topic><topic>Graves Disease - blood</topic><topic>Graves Disease - immunology</topic><topic>Helper cells</topic><topic>Humans</topic><topic>Hyperthyroidism</topic><topic>Interferon</topic><topic>Interferon-gamma - blood</topic><topic>Interferon-gamma - immunology</topic><topic>Interleukin 17</topic><topic>Interleukin 22</topic><topic>Interleukin-17 - blood</topic><topic>Interleukin-17 - immunology</topic><topic>Interleukins - blood</topic><topic>Interleukins - immunology</topic><topic>Laboratories</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Peripheral blood</topic><topic>Psoriasis</topic><topic>Radioimmunoassay</topic><topic>Rheumatoid arthritis</topic><topic>Th1 Cells - immunology</topic><topic>Th17 Cells - immunology</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid hormones</topic><topic>Thyroid-stimulating hormone</topic><topic>Thyroid-stimulating hormone receptors</topic><topic>Thyrotropin - blood</topic><topic>Thyrotropin - immunology</topic><topic>Thyroxine</topic><topic>Thyroxine - blood</topic><topic>Thyroxine - immunology</topic><topic>Triiodothyronine</topic><topic>Triiodothyronine - blood</topic><topic>Triiodothyronine - immunology</topic><topic>Young Adult</topic><topic>Zoonoses</topic><topic>γ-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peng, Di</creatorcontrib><creatorcontrib>Xu, Bingchuan</creatorcontrib><creatorcontrib>Wang, Ye</creatorcontrib><creatorcontrib>Guo, Hui</creatorcontrib><creatorcontrib>Jiang, Yanfang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Di</au><au>Xu, Bingchuan</au><au>Wang, Ye</au><au>Guo, Hui</au><au>Jiang, Yanfang</au><au>Fang, Deyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A high frequency of circulating th22 and th17 cells in patients with new onset graves' disease</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-07-11</date><risdate>2013</risdate><volume>8</volume><issue>7</issue><spage>e68446</spage><epage>e68446</epage><pages>e68446-e68446</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>T-helper (Th) 22 and Th17 cells are involved in the pathogenesis of autoimmune diseases. However, their roles in the pathogenesis of Graves'disease (GD) are unclear. This study is aimed at examining the frequency of peripheral blood Th22, Th17, and Th1 cells and the levels of plasma IL-22, IL-17, and IFN-γ in patients with GD. A total of 27 patients with new onset GD and 27 gender- and age-matched healthy controls (HC) were examined for the frequency of peripheral blood Th22, Th17, and IFN-γ cells by flow cytometry. The concentrations of plasma IL-22, IL-17, and IFN-γ were examined by enzyme-linked immunosorbent assay. The levels of serum TSHR antibodies (A-TSHR), free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) were examined by radioimmunoassay and chemiluminescent assay, respectively. The levels of serum TSAb were examined by enzyme-linked immunosorbent assay. In comparison with those in the HC, significantly elevated percentages of Th22 and Th17 cells, but not Th1 cells, and increased levels of plasma IL-22 and IL-17, but not IFN-γ, were detected in GD patients (P<0.0001, for both). The percentages of both Th22 and Th17 cells and the levels of plasma IL-22 and IL-17 were correlated positively with the levels of serum TSAb in GD patients (r = 0.7944, P<0.0001; r = 0.8110, P<0.0001; r = 0.7101, p<0.0001; r = 0.7407, p<0.0001, respectively). Th22 and Th17 cells may contribute to the pathogenesis of GD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23874630</pmid><doi>10.1371/journal.pone.0068446</doi><tpages>e68446</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Analysis Antibodies Autoimmune diseases Blood CD4-Positive T-Lymphocytes - immunology Chemiluminescence Cytokines Cytometry Disease Enzyme-linked immunosorbent assay Enzymes Female Flow cytometry Gender Graves Disease - blood Graves Disease - immunology Helper cells Humans Hyperthyroidism Interferon Interferon-gamma - blood Interferon-gamma - immunology Interleukin 17 Interleukin 22 Interleukin-17 - blood Interleukin-17 - immunology Interleukins - blood Interleukins - immunology Laboratories Lymphocytes Lymphocytes T Male Medicine Middle Aged Pathogenesis Patients Peripheral blood Psoriasis Radioimmunoassay Rheumatoid arthritis Th1 Cells - immunology Th17 Cells - immunology Thyroid Thyroid gland Thyroid hormones Thyroid-stimulating hormone Thyroid-stimulating hormone receptors Thyrotropin - blood Thyrotropin - immunology Thyroxine Thyroxine - blood Thyroxine - immunology Triiodothyronine Triiodothyronine - blood Triiodothyronine - immunology Young Adult Zoonoses γ-Interferon |
| title | A high frequency of circulating th22 and th17 cells in patients with new onset graves' disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-11T10%3A16%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20high%20frequency%20of%20circulating%20th22%20and%20th17%20cells%20in%20patients%20with%20new%20onset%20graves'%20disease&rft.jtitle=PloS%20one&rft.au=Peng,%20Di&rft.date=2013-07-11&rft.volume=8&rft.issue=7&rft.spage=e68446&rft.epage=e68446&rft.pages=e68446-e68446&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0068446&rft_dat=%3Cgale_plos_%3EA478325894%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1399533027&rft_id=info:pmid/23874630&rft_galeid=A478325894&rft_doaj_id=oai_doaj_org_article_b030d1eeb5a04c85a351207351d80ec0&rfr_iscdi=true |