Evolution of the plasma and tissue kallikreins, and their alternative splicing isoforms

Kallikreins are secreted serine proteases with important roles in human physiology. Human plasma kallikrein, encoded by the KLKB1 gene on locus 4q34-35, functions in the blood coagulation pathway, and in regulating blood pressure. The human tissue kallikrein and kallikrein-related peptidases (KLKs)...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e68074-e68074
Hauptverfasser:	Koumandou, Vassiliki Lila, Scorilas, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Alternative Splicing - genetics Amino Acid Sequence Amino acids Amphibia Amphibians Angiogenesis Bayesian analysis Biology Biomarkers Blood Blood coagulation Blood plasma Blood pressure Cancer Catalysis Cell growth Chromosome 4 Chymotrypsin Cladistic analysis Coagulation Complement factor D Conservation Conserved Sequence Divergence Evolution Evolution, Molecular Evolutionary biology Gene duplication Genomes Genomics Homology Humans Hydrolases Isoforms Kallikrein KLK gene KLK3 gene KLKB1 gene Mammals Metastases Molecular Sequence Data Next-generation sequencing Ovarian cancer Peptidases Phylogeny Physiological aspects Physiology Plasma kallikrein Plasma Kallikrein - chemistry Plasma Kallikrein - genetics Prostate Prostate cancer Prostate specific antigen Protease Protein Conformation Protein Isoforms - chemistry Protein Isoforms - genetics Protein Structure, Tertiary Proteinase Sequence Homology Serine Tissue Kallikreins - chemistry Tissue Kallikreins - genetics Tissues Trypsin Wildlife conservation
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