Venous thromboembolism in an industrial north american city: temporal distribution and association with particulate matter air pollution
Emerging evidence, mainly from Europe and Asia, indicates that venous thromboembolism (VTE) occurs most often in winter. Factors implicated in such seasonality are low temperature-mediated exacerbation of coagulation and high levels of particulate matter (PM) air pollution. However, in contrast to m...
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| description | Emerging evidence, mainly from Europe and Asia, indicates that venous thromboembolism (VTE) occurs most often in winter. Factors implicated in such seasonality are low temperature-mediated exacerbation of coagulation and high levels of particulate matter (PM) air pollution. However, in contrast to most European and Asian cities, particulate matter pollution peaks in the summer in many North American cities.
We aimed to exploit this geographical difference and examine the temporal distribution of VTE in a cold-weather, North American city, Detroit, with a summer PM peak. Our goal was thereby to resolve the influence of temperature and PM levels on VTE.
Our retrospective, analytical semi-ecological study used chart review to confirm 1,907 acute, ambulatory VTE cases, divided them by location (Detroit versus suburban), and plotted monthly VTE frequency distributions. We used Environmental Protection Agency data to determine the temporal distribution of PM pollution components in Detroit. Suburban PM air pollution is presumed negligible and therefore not monitored.
Acute VTE cases in Detroit (1,490) exhibited a summer peak (June 24(th)) and differed from both a uniform distribution (P |
| doi_str_mv | 10.1371/journal.pone.0068829 |
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We aimed to exploit this geographical difference and examine the temporal distribution of VTE in a cold-weather, North American city, Detroit, with a summer PM peak. Our goal was thereby to resolve the influence of temperature and PM levels on VTE.
Our retrospective, analytical semi-ecological study used chart review to confirm 1,907 acute, ambulatory VTE cases, divided them by location (Detroit versus suburban), and plotted monthly VTE frequency distributions. We used Environmental Protection Agency data to determine the temporal distribution of PM pollution components in Detroit. Suburban PM air pollution is presumed negligible and therefore not monitored.
Acute VTE cases in Detroit (1,490) exhibited a summer peak (June 24(th)) and differed from both a uniform distribution (P<0.01) and also that of 1,123 no-VTE cases (P<0.02). Levels of 10 µm diameter PM and coarse particle (2.5 to 10 µm) PM also exhibited summer peaks versus a winter peak for 2.5 µm diameter PM. Contrary to their urban counterparts, suburban cases of acute VTE (417) showed no monthly variation.
The summer peak of acute VTE in Detroit indicates that low temperature is not a major factor in VTE pathogenesis. In contrast, concordance of the 10 µm diameter PM, coarse particle, and the Detroit VTE monthly distributions, combined with no monthly suburban VTE variation, is consistent with a role for PM pollution. Furthermore, divergence of the VTE and 2.5 µm PM distributions suggests that particle size may play a role.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0068829</identifier><identifier>PMID: 23874781</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Air pollution ; Air Pollution - analysis ; Air Pollution - statistics & numerical data ; Blood clots ; Cities - epidemiology ; Coagulation ; Cold weather ; Divergence ; Earth Sciences ; Ecological monitoring ; Ecological studies ; Emergency medical care ; Environmental monitoring ; Environmental protection ; Ethnicity ; Female ; Health risk assessment ; Hospitals ; Humans ; Industry ; Low temperature ; Male ; Mathematical analysis ; Medical records ; Medicine ; Middle Aged ; Monthly variations ; North America - epidemiology ; Particulate emissions ; Particulate matter ; Particulate Matter - analysis ; Particulates ; Pathogenesis ; Pollution ; Pollution monitoring ; Retrospective Studies ; Seasonal variations ; Seasons ; Spatio-Temporal Analysis ; Studies ; Suburban areas ; Summer ; Temperature effects ; Temporal distribution ; Thromboembolism ; Thrombosis ; Time Factors ; United States - epidemiology ; Veins & arteries ; Venous Thromboembolism - epidemiology ; Venous Thromboembolism - etiology ; Weather ; Winter</subject><ispartof>PloS one, 2013-07, Vol.8 (7), p.e68829</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Chiu, Whittaker. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Chiu, Whittaker 2013 Chiu, Whittaker</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-43646c0837e5497c61966d880223565ed2899ca9997fb4a548edf461873656bd3</citedby><cites>FETCH-LOGICAL-c692t-43646c0837e5497c61966d880223565ed2899ca9997fb4a548edf461873656bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707887/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707887/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23874781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chiu, Holly H</creatorcontrib><creatorcontrib>Whittaker, Peter</creatorcontrib><title>Venous thromboembolism in an industrial north american city: temporal distribution and association with particulate matter air pollution</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Emerging evidence, mainly from Europe and Asia, indicates that venous thromboembolism (VTE) occurs most often in winter. Factors implicated in such seasonality are low temperature-mediated exacerbation of coagulation and high levels of particulate matter (PM) air pollution. However, in contrast to most European and Asian cities, particulate matter pollution peaks in the summer in many North American cities.
We aimed to exploit this geographical difference and examine the temporal distribution of VTE in a cold-weather, North American city, Detroit, with a summer PM peak. Our goal was thereby to resolve the influence of temperature and PM levels on VTE.
Our retrospective, analytical semi-ecological study used chart review to confirm 1,907 acute, ambulatory VTE cases, divided them by location (Detroit versus suburban), and plotted monthly VTE frequency distributions. We used Environmental Protection Agency data to determine the temporal distribution of PM pollution components in Detroit. Suburban PM air pollution is presumed negligible and therefore not monitored.
Acute VTE cases in Detroit (1,490) exhibited a summer peak (June 24(th)) and differed from both a uniform distribution (P<0.01) and also that of 1,123 no-VTE cases (P<0.02). Levels of 10 µm diameter PM and coarse particle (2.5 to 10 µm) PM also exhibited summer peaks versus a winter peak for 2.5 µm diameter PM. Contrary to their urban counterparts, suburban cases of acute VTE (417) showed no monthly variation.
The summer peak of acute VTE in Detroit indicates that low temperature is not a major factor in VTE pathogenesis. In contrast, concordance of the 10 µm diameter PM, coarse particle, and the Detroit VTE monthly distributions, combined with no monthly suburban VTE variation, is consistent with a role for PM pollution. Furthermore, divergence of the VTE and 2.5 µm PM distributions suggests that particle size may play a role.</description><subject>Air pollution</subject><subject>Air Pollution - analysis</subject><subject>Air Pollution - statistics & numerical data</subject><subject>Blood clots</subject><subject>Cities - epidemiology</subject><subject>Coagulation</subject><subject>Cold weather</subject><subject>Divergence</subject><subject>Earth Sciences</subject><subject>Ecological monitoring</subject><subject>Ecological studies</subject><subject>Emergency medical care</subject><subject>Environmental monitoring</subject><subject>Environmental protection</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Industry</subject><subject>Low temperature</subject><subject>Male</subject><subject>Mathematical analysis</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Monthly variations</subject><subject>North America - epidemiology</subject><subject>Particulate emissions</subject><subject>Particulate matter</subject><subject>Particulate Matter - analysis</subject><subject>Particulates</subject><subject>Pathogenesis</subject><subject>Pollution</subject><subject>Pollution monitoring</subject><subject>Retrospective Studies</subject><subject>Seasonal variations</subject><subject>Seasons</subject><subject>Spatio-Temporal Analysis</subject><subject>Studies</subject><subject>Suburban areas</subject><subject>Summer</subject><subject>Temperature effects</subject><subject>Temporal distribution</subject><subject>Thromboembolism</subject><subject>Thrombosis</subject><subject>Time Factors</subject><subject>United States - epidemiology</subject><subject>Veins & arteries</subject><subject>Venous Thromboembolism - epidemiology</subject><subject>Venous Thromboembolism - etiology</subject><subject>Weather</subject><subject>Winter</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk2uL1DAUhoso7jr6D0QLguCHGXNrLn4QlsXLwMKCl_0a0iSdydI23SRV9x_4s83MdJcpKEjpLed5T0_fnFMUzyFYQczg22s_hl61q8H3dgUA5RyJB8UpFBgtKQL44dHzSfEkxmsAKswpfVycIMwZYRyeFr-vbO_HWKZt8F3tbT5bF7vS9aXq89WMMQWn2rL3IW1L1dngdI5ol27flcl2gw85atwOq8fk_E5oShWj107t33-6rBxUSE6PrUq27FRKNpTKhXLwbbtXPS0eNaqN9tl0XxTfP374dv55eXH5aX1-drHUVKC0JJgSqgHHzFZEME2hoNRwDhDCFa2sQVwIrYQQrKmJqgi3piEUcoZpRWuDF8XLQ96h9VFOJkYJsRBIVKCqMrE-EMarazkE16lwK71ycr_gw0bu_6W1stEE1rVCqAaMEFMJlS0X0KJcSNVQknO9n7421p012vYp2zVLOo_0bis3_ofEDDCei14Ur6YEwd-MNqZ_lDxRG5Wrcn3jczLduajlWd5nTDDjIlOrv1D5MLZzOrdR4_L6TPBmJshMsr_SRo0xyvXXL__PXl7N2ddH7NaqNm2jP_RBnIPkAOrgYwy2uXcOArmbgjs35G4K5DQFWfbi2PV70V3b4z9RogUb</recordid><startdate>20130710</startdate><enddate>20130710</enddate><creator>Chiu, Holly H</creator><creator>Whittaker, Peter</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130710</creationdate><title>Venous thromboembolism in an industrial north american city: temporal distribution and association with particulate matter air pollution</title><author>Chiu, Holly H ; Whittaker, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-43646c0837e5497c61966d880223565ed2899ca9997fb4a548edf461873656bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Air pollution</topic><topic>Air Pollution - 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epidemiology</topic><topic>Veins & arteries</topic><topic>Venous Thromboembolism - epidemiology</topic><topic>Venous Thromboembolism - etiology</topic><topic>Weather</topic><topic>Winter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chiu, Holly H</creatorcontrib><creatorcontrib>Whittaker, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints Resource Center</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Database (1962 - 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Factors implicated in such seasonality are low temperature-mediated exacerbation of coagulation and high levels of particulate matter (PM) air pollution. However, in contrast to most European and Asian cities, particulate matter pollution peaks in the summer in many North American cities.
We aimed to exploit this geographical difference and examine the temporal distribution of VTE in a cold-weather, North American city, Detroit, with a summer PM peak. Our goal was thereby to resolve the influence of temperature and PM levels on VTE.
Our retrospective, analytical semi-ecological study used chart review to confirm 1,907 acute, ambulatory VTE cases, divided them by location (Detroit versus suburban), and plotted monthly VTE frequency distributions. We used Environmental Protection Agency data to determine the temporal distribution of PM pollution components in Detroit. Suburban PM air pollution is presumed negligible and therefore not monitored.
Acute VTE cases in Detroit (1,490) exhibited a summer peak (June 24(th)) and differed from both a uniform distribution (P<0.01) and also that of 1,123 no-VTE cases (P<0.02). Levels of 10 µm diameter PM and coarse particle (2.5 to 10 µm) PM also exhibited summer peaks versus a winter peak for 2.5 µm diameter PM. Contrary to their urban counterparts, suburban cases of acute VTE (417) showed no monthly variation.
The summer peak of acute VTE in Detroit indicates that low temperature is not a major factor in VTE pathogenesis. In contrast, concordance of the 10 µm diameter PM, coarse particle, and the Detroit VTE monthly distributions, combined with no monthly suburban VTE variation, is consistent with a role for PM pollution. Furthermore, divergence of the VTE and 2.5 µm PM distributions suggests that particle size may play a role.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23874781</pmid><doi>10.1371/journal.pone.0068829</doi><tpages>e68829</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Air pollution Air Pollution - analysis Air Pollution - statistics & numerical data Blood clots Cities - epidemiology Coagulation Cold weather Divergence Earth Sciences Ecological monitoring Ecological studies Emergency medical care Environmental monitoring Environmental protection Ethnicity Female Health risk assessment Hospitals Humans Industry Low temperature Male Mathematical analysis Medical records Medicine Middle Aged Monthly variations North America - epidemiology Particulate emissions Particulate matter Particulate Matter - analysis Particulates Pathogenesis Pollution Pollution monitoring Retrospective Studies Seasonal variations Seasons Spatio-Temporal Analysis Studies Suburban areas Summer Temperature effects Temporal distribution Thromboembolism Thrombosis Time Factors United States - epidemiology Veins & arteries Venous Thromboembolism - epidemiology Venous Thromboembolism - etiology Weather Winter |
| title | Venous thromboembolism in an industrial north american city: temporal distribution and association with particulate matter air pollution |
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