Distinct patterns of cerebral extravasation by Evans blue and sodium fluorescein in rats

The Evans blue dye (EBD; 961 Da) and the sodium fluorescein dye (NaF; 376 Da) are commonly used inert tracers in blood-brain barrier (BBB) research. They are both highly charged low molecular weight (LMW) tracers with similar lipophobic profiles. Nevertheless, the EBD binds to serum albumin (69,000...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e68595-e68595
Hauptverfasser:	Yen, Lola Fenghuei, Wei, Vivi Chiali, Kuo, Eva Yuhua, Lai, Ted Weita
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Albumin Animals Blood circulation Blood-brain barrier Blood-Brain Barrier - metabolism Brain Brain research Capillary Permeability Cerebellum Cerebrum - metabolism Drug delivery systems Dyes Evans Blue - administration & dosage Evans Blue - metabolism Extravasation Extravasation of Diagnostic and Therapeutic Materials Fluorescein Fluorescein - administration & dosage Fluorescein - metabolism Fluorescent indicators Fluorides Low molecular weights Male Molecular weight Neostriatum Permeability Prefrontal cortex Proteins Rats Rodents Serum albumin Sodium Tracers
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