Plant derived aporphinic alkaloid S-(+)-dicentrine induces antinociceptive effect in both acute and chronic inflammatory pain models: evidence for a role of TRPA1 channels

S-(+)-dicentrine is an aporphinic alkaloid found in several plant species, mainly from Lauraceae family, which showed significant antinociceptive activity in an acute model of visceral pain in mice. In this work, we extended the knowledge on the antinociceptive properties of S-(+)-dicentrine and sho...

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Veröffentlicht in:PloS one 2013-07, Vol.8 (7), p.e67730
Hauptverfasser: Montrucchio, Deise Prehs, Córdova, Marina Machado, Santos, Adair Roberto Soares
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Sprache:eng
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