Nickel ion inhibits nuclear factor-kappa B activity in human oral squamous cell carcinoma

The spontaneous IL-8 secretion observed in OSCC is partially dependent on the disregulated activity of transcription factor NF-κB. Nickel compounds are well established human carcinogens, however, little is known about the influence of nickel on the spontaneous secretion of IL-8 in oral squamous cel...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e68257
Hauptverfasser:	Shionome, Takashi, Endo, Shigeki, Omagari, Daisuke, Asano, Masatake, Toyoma, Hitoshi, Ishigami, Tomohiko, Komiyama, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Assaying Cancer Carcinogens Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Cell Line, Tumor Cell Movement - drug effects Clusters Dentistry E coli Enzyme Activation - drug effects Enzyme-linked immunosorbent assay Escherichia coli Gene Expression Heavy Ions - adverse effects Humans Immunofluorescence Interleukin 8 Interleukin-8 - biosynthesis Ions Kinases Localization Materials Science Medicine Mobility Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Mutagenesis Mutants Mutation N-Terminus NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism NF-kappa B p50 Subunit - genetics NF-kappa B p50 Subunit - metabolism NF-κB protein Nickel Nickel - pharmacology Nickel compounds Nuclei Oral cancer Oral squamous cell carcinoma Pathology Phosphorylation Protein Binding Protein Transport - drug effects Proteins RNA Rodents Site-directed mutagenesis Squamous cell carcinoma Staining Studies Toll-Like Receptor 4 - metabolism Western blotting
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