Aristaless related homeobox gene, Arx, is implicated in mouse fetal Leydig cell differentiation possibly through expressing in the progenitor cells

Development of the testis begins with the expression of the SRY gene in pre-Sertoli cells. Soon after, testis cords containing Sertoli and germ cells are formed and fetal Leydig cells subsequently develop in the interstitial space. Studies using knockout mice have indicated that multiple genes encod...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e68050-e68050
Hauptverfasser:	Miyabayashi, Kanako, Katoh-Fukui, Yuko, Ogawa, Hidesato, Baba, Takashi, Shima, Yuichi, Sugiyama, Noriyuki, Kitamura, Kunio, Morohashi, Ken-ichirou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ARX protein Biology Cell differentiation Cell Differentiation - genetics Cell Proliferation Cells (biology) Cords Defects Differentiation (biology) Endocrinology Epithelial cells Epithelial Cells - physiology Epithelium Epithelium - physiology Fetus - physiology Fetuses Gene expression Genes Genes, Homeobox - genetics Germ cells Germ Cells - growth & development Germ Cells - physiology Gonads Gonads - growth & development Gonads - physiology Growth factors Homeobox Homeodomain Proteins - genetics Interstitial cells Leydig cells Leydig Cells - physiology Male Mammals Mesonephros - growth & development Mesonephros - physiology Mice Mice, Inbred ICR Mice, Knockout Molecular biology Proteins Rodents Sertoli cells Sex Differentiation - genetics Stem cells Stem Cells - pathology Studies Testes Testis - growth & development Testis - physiology Testosterone Transcription factors Transcription Factors - genetics
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