An atypical age-specific pattern of hepatocellular carcinoma in Peru: a threat for Andean populations
In South America, the highest incidence of primary liver cancer is observed in Peru. However, national estimations on hepatocellular carcinoma incidence and mortality are approximated using aggregated data from surrounding countries. Thus, there is a lack of tangible information from Peru that impai...
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| creator | Bertani, Stéphane Pineau, Pascal Loli, Sebastian Moura, Julien Zimic, Mirko Deharo, Eric Ruiz, Eloy |
| description | In South America, the highest incidence of primary liver cancer is observed in Peru. However, national estimations on hepatocellular carcinoma incidence and mortality are approximated using aggregated data from surrounding countries. Thus, there is a lack of tangible information from Peru that impairs an accurate description of the local incidence, presentation, and outcomes of hepatocellular carcinoma. The present study attempts to fill this gap and assesses the clinical epidemiology of hepatocellular carcinoma in this country.
A retrospective cohort study was conducted by analysing the medical charts of 1,541 patients with hepatocellular carcinoma admitted between 1997 and 2010 at the Peruvian national institute for cancer. The medical records including liver function, serologic status, and tumor pathology and stage were monitored. Statistical analyses were performed in order to characterize tumor presentation according to demographic features, risk factors, and regional origin.
Surprisingly, the age distribution of the patient population displayed bimodality corresponding to two distinct age-based subpopulations. While an older group was in keeping with the age range observed for hepatocellular carcinoma around the world, a younger population displayed an abnormally juvenile mean age of 25.5 years old. In addition, each subpopulation displayed age-specific pathophysiological and clinical characteristics.
The analysis suggests two different age-specific natural histories of hepatocellular carcinoma in the Peruvian patient population. This otherwise unusual tumor process that is ongoing in younger patients leads to the hypothesis that there may be a Peru-endemic risk factor driving hepatocarcinogenesis in the local population. |
| doi_str_mv | 10.1371/journal.pone.0067756 |
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A retrospective cohort study was conducted by analysing the medical charts of 1,541 patients with hepatocellular carcinoma admitted between 1997 and 2010 at the Peruvian national institute for cancer. The medical records including liver function, serologic status, and tumor pathology and stage were monitored. Statistical analyses were performed in order to characterize tumor presentation according to demographic features, risk factors, and regional origin.
Surprisingly, the age distribution of the patient population displayed bimodality corresponding to two distinct age-based subpopulations. While an older group was in keeping with the age range observed for hepatocellular carcinoma around the world, a younger population displayed an abnormally juvenile mean age of 25.5 years old. In addition, each subpopulation displayed age-specific pathophysiological and clinical characteristics.
The analysis suggests two different age-specific natural histories of hepatocellular carcinoma in the Peruvian patient population. This otherwise unusual tumor process that is ongoing in younger patients leads to the hypothesis that there may be a Peru-endemic risk factor driving hepatocarcinogenesis in the local population.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0067756</identifier><identifier>PMID: 23840771</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abdomen ; Adolescent ; Adult ; Age ; Age composition ; Age Distribution ; Aged ; Aged, 80 and over ; Cancer ; Carcinoma, Hepatocellular - epidemiology ; Carcinoma, Hepatocellular - mortality ; Charts ; Child ; Child, Preschool ; Cohort Studies ; Demographics ; Epidemiology ; Family medical history ; Female ; Gene expression ; Hepatitis ; Hepatocellular carcinoma ; Hospitals ; Human health and pathology ; Humans ; Hépatology and Gastroenterology ; Incidence ; Infant ; Infant, Newborn ; Infections ; Life Sciences ; Liver ; Liver cancer ; Liver cirrhosis ; Liver Neoplasms - epidemiology ; Liver Neoplasms - mortality ; Local population ; Male ; Medical records ; Medicine ; Middle Aged ; Mortality ; Normal distribution ; Patients ; Peru - epidemiology ; Population (statistical) ; Retrospective Studies ; Risk analysis ; Risk Factors ; Santé publique et épidémiologie ; Statistical analysis ; Stem cells ; Subpopulations ; Tumors ; Young Adult</subject><ispartof>PloS one, 2013-06, Vol.8 (6), p.e67756-e67756</ispartof><rights>2013 Bertani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Attribution</rights><rights>2013 Bertani et al 2013 Bertani et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c560t-2beef0f025912559b1d22e1abf5434efaf1c344d5d72421396ac1d7a3dffcc533</citedby><cites>FETCH-LOGICAL-c560t-2beef0f025912559b1d22e1abf5434efaf1c344d5d72421396ac1d7a3dffcc533</cites><orcidid>0000-0002-5664-9517 ; 0000-0002-9407-1592 ; 0000-0002-0398-9745</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695993/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695993/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23840771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01356600$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Bertani, Stéphane</creatorcontrib><creatorcontrib>Pineau, Pascal</creatorcontrib><creatorcontrib>Loli, Sebastian</creatorcontrib><creatorcontrib>Moura, Julien</creatorcontrib><creatorcontrib>Zimic, Mirko</creatorcontrib><creatorcontrib>Deharo, Eric</creatorcontrib><creatorcontrib>Ruiz, Eloy</creatorcontrib><title>An atypical age-specific pattern of hepatocellular carcinoma in Peru: a threat for Andean populations</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>In South America, the highest incidence of primary liver cancer is observed in Peru. However, national estimations on hepatocellular carcinoma incidence and mortality are approximated using aggregated data from surrounding countries. Thus, there is a lack of tangible information from Peru that impairs an accurate description of the local incidence, presentation, and outcomes of hepatocellular carcinoma. The present study attempts to fill this gap and assesses the clinical epidemiology of hepatocellular carcinoma in this country.
A retrospective cohort study was conducted by analysing the medical charts of 1,541 patients with hepatocellular carcinoma admitted between 1997 and 2010 at the Peruvian national institute for cancer. The medical records including liver function, serologic status, and tumor pathology and stage were monitored. Statistical analyses were performed in order to characterize tumor presentation according to demographic features, risk factors, and regional origin.
Surprisingly, the age distribution of the patient population displayed bimodality corresponding to two distinct age-based subpopulations. While an older group was in keeping with the age range observed for hepatocellular carcinoma around the world, a younger population displayed an abnormally juvenile mean age of 25.5 years old. In addition, each subpopulation displayed age-specific pathophysiological and clinical characteristics.
The analysis suggests two different age-specific natural histories of hepatocellular carcinoma in the Peruvian patient population. 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bertani, Stéphane</au><au>Pineau, Pascal</au><au>Loli, Sebastian</au><au>Moura, Julien</au><au>Zimic, Mirko</au><au>Deharo, Eric</au><au>Ruiz, Eloy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An atypical age-specific pattern of hepatocellular carcinoma in Peru: a threat for Andean populations</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-06-28</date><risdate>2013</risdate><volume>8</volume><issue>6</issue><spage>e67756</spage><epage>e67756</epage><pages>e67756-e67756</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>In South America, the highest incidence of primary liver cancer is observed in Peru. However, national estimations on hepatocellular carcinoma incidence and mortality are approximated using aggregated data from surrounding countries. Thus, there is a lack of tangible information from Peru that impairs an accurate description of the local incidence, presentation, and outcomes of hepatocellular carcinoma. The present study attempts to fill this gap and assesses the clinical epidemiology of hepatocellular carcinoma in this country.
A retrospective cohort study was conducted by analysing the medical charts of 1,541 patients with hepatocellular carcinoma admitted between 1997 and 2010 at the Peruvian national institute for cancer. The medical records including liver function, serologic status, and tumor pathology and stage were monitored. Statistical analyses were performed in order to characterize tumor presentation according to demographic features, risk factors, and regional origin.
Surprisingly, the age distribution of the patient population displayed bimodality corresponding to two distinct age-based subpopulations. While an older group was in keeping with the age range observed for hepatocellular carcinoma around the world, a younger population displayed an abnormally juvenile mean age of 25.5 years old. In addition, each subpopulation displayed age-specific pathophysiological and clinical characteristics.
The analysis suggests two different age-specific natural histories of hepatocellular carcinoma in the Peruvian patient population. This otherwise unusual tumor process that is ongoing in younger patients leads to the hypothesis that there may be a Peru-endemic risk factor driving hepatocarcinogenesis in the local population.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23840771</pmid><doi>10.1371/journal.pone.0067756</doi><orcidid>https://orcid.org/0000-0002-5664-9517</orcidid><orcidid>https://orcid.org/0000-0002-9407-1592</orcidid><orcidid>https://orcid.org/0000-0002-0398-9745</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-06, Vol.8 (6), p.e67756-e67756 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1372350736 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Abdomen Adolescent Adult Age Age composition Age Distribution Aged Aged, 80 and over Cancer Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - mortality Charts Child Child, Preschool Cohort Studies Demographics Epidemiology Family medical history Female Gene expression Hepatitis Hepatocellular carcinoma Hospitals Human health and pathology Humans Hépatology and Gastroenterology Incidence Infant Infant, Newborn Infections Life Sciences Liver Liver cancer Liver cirrhosis Liver Neoplasms - epidemiology Liver Neoplasms - mortality Local population Male Medical records Medicine Middle Aged Mortality Normal distribution Patients Peru - epidemiology Population (statistical) Retrospective Studies Risk analysis Risk Factors Santé publique et épidémiologie Statistical analysis Stem cells Subpopulations Tumors Young Adult |
| title | An atypical age-specific pattern of hepatocellular carcinoma in Peru: a threat for Andean populations |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T04%3A44%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20atypical%20age-specific%20pattern%20of%20hepatocellular%20carcinoma%20in%20Peru:%20a%20threat%20for%20Andean%20populations&rft.jtitle=PloS%20one&rft.au=Bertani,%20St%C3%A9phane&rft.date=2013-06-28&rft.volume=8&rft.issue=6&rft.spage=e67756&rft.epage=e67756&rft.pages=e67756-e67756&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0067756&rft_dat=%3Cproquest_plos_%3E1399504873%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1372350736&rft_id=info:pmid/23840771&rft_doaj_id=oai_doaj_org_article_4b877a47dc97410999266bbe18509755&rfr_iscdi=true |