The combination of a low-dose chemotherapeutic agent, 5-fluorouracil, and an adenoviral tumor vaccine has a synergistic benefit on survival in a tumor model system

Standard cancer therapies, particularly those involving chemotherapy, are in need of modifications that both reduce short-term and long-term side effects as well as improve the overall survival of cancer patients. Here we show that combining low-dose chemotherapy with a therapeutic vaccination using...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e67904
Hauptverfasser:	Geary, Sean M, Lemke, Caitlin D, Lubaroff, David M, Salem, Aliasger K
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Adenoviridae - immunology Adenoviruses Animals Antigen (tumor-associated) Antigens Antigens, Neoplasm - immunology Antineoplastic Agents - administration & dosage Antineoplastic Agents - immunology Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - immunology Biology Cancer Cancer therapies Cancer vaccines Cancer Vaccines - administration & dosage Cancer Vaccines - immunology CD8 antigen CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Chemotherapy Clinical trials Combinatorial analysis Dendritic cells Dosage Drug dosages Drug Synergism Fluorouracil - administration & dosage Fluorouracil - immunology Granulocytes Immune response Immune system Immunotherapy Lymph nodes Lymph Nodes - drug effects Lymph Nodes - immunology Lymphatic system Lymphocytes Lymphocytes T Male Medicine Mice Mice, Inbred C57BL Ovalbumin Ovalbumin - administration & dosage Ovalbumin - immunology Pharmaceutical sciences Pharmacy Rodents Side effects Spleen - drug effects Spleen - immunology Studies Survival Survival Rate Tumors Vaccines
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