Regulation of Transcriptional Networks by PKC Isozymes: Identification of c-Rel as a Key Transcription Factor for PKC-Regulated Genes

Activation of protein kinase C (PKC), a family of serine-threonine kinases widely implicated in cancer progression, has major impact on gene expression. In a recent genome-wide analysis of prostate cancer cells we identified distinctive gene expression profiles controlled by individual PKC isozymes...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e67319-e67319
Hauptverfasser:	Garg, Rachana, Caino, M Cecilia, Kazanietz, Marcelo G
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Apoptosis Bioinformatics Biological activity Biology Cancer Cell cycle Cyclic AMP response element-binding protein Diglycerides Gene expression Gene Expression Regulation, Neoplastic Gene regulation Gene Regulatory Networks Genes Genomes Humans Inflammation Inflammatory response Isoenzymes Kinases Laboratories Male Medical research Medicine Networks NF-κB protein Oct-1 protein Pharmacology Promoter Regions, Genetic Promoters Prostate cancer Prostatic Neoplasms - enzymology Prostatic Neoplasms - genetics Protein kinase C Protein Kinase C - genetics Proteins Proto-Oncogene Proteins c-rel - genetics Proto-Oncogene Proteins c-rel - metabolism Regulatory Elements, Transcriptional RNA-mediated interference Serine Threonine Transcription activation Transcription factors Transcriptional Activation Tumor Cells, Cultured
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