Modeling the Insulin-Like Growth Factor System in Articular Cartilage

IGF signaling is involved in cell proliferation, differentiation and apoptosis in a wide range of tissues, both normal and diseased, and so IGF-IR has been the focus of intense interest as a promising drug target. In this computational study on cartilage, we focus on two questions: (i) what are the...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e66870-e66870
Hauptverfasser:	Zhang, Lihai, Smith, David W, Gardiner, Bruce S, Grodzinsky, Alan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Arthritis Binding sites Biology Cancer Cartilage Cartilage (articular) Cartilage, Articular - cytology Cartilage, Articular - metabolism Cell proliferation Cellular manufacture Complex formation Computation Computer applications Computer engineering Computer Science Extracellular matrix Growth hormones Half life Homeostasis Humans Insulin Insulin - metabolism Insulin-like growth factor I Insulin-Like Growth Factor I - metabolism Insulin-like growth factor II Insulin-Like Growth Factor II - metabolism Insulin-like growth factors Iridium Joint surgery Kinases Ligands Medicine Models, Biological Negative feedback Parameter identification Parameter sensitivity Proteins Signal Transduction Signaling Tissues
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